{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T01:31:36Z","timestamp":1789781496542,"version":"4.0.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The tight-skin (TSK\/+) mouse, a genetic model for systemic sclerosis, develops cutaneous fibrosis. Although a fibrillin 1 gene mutation and immunological abnormalities have been demonstrated, the roles of adhesion molecules have not been investigated. To directly assess roles of adhesion molecules in skin fibrosis, TSK\/+ mice lacking L-selectin and\/or ICAM-1 were generated. The deficiency of ICAM-1, but not L-selectin, significantly suppressed (\u223c48%) the development of skin sclerosis in TSK\/+ mice. Similarly, ICAM-1 antisense oligonucleotides inhibited skin fibrosis in TSK\/+ mice. Although T cell infiltration was modest into the skin of TSK\/+ mice, ICAM-1 deficiency down-regulated this migration, which is consistent with the established roles of endothelial ICAM-1 in leukocyte infiltration. In addition, altered phenotype or function of skin fibroblasts was remarkable and dependent on ICAM-1 expression in TSK\/+ mice. ICAM-1 expression was augmented on TSK\/+ dermal fibroblasts stimulated with IL-4. Although growth or collagen synthesis of TSK\/+ fibroblasts cultured with IL-4 was up-regulated, it was suppressed by the loss or blocking of ICAM-1. Collagen expression was dependent on the strain of fibroblasts, but not on the strain of cocultured T cells. Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK\/+ mice, especially via ICAM-1 expressed on skin fibroblasts.<\/jats:p>","DOI":"10.4049\/jimmunol.179.1.698","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:38:23Z","timestamp":1397864303000},"page":"698-707","source":"Crossref","is-referenced-by-count":34,"title":["Intercellular Adhesion Molecule-1 Deficiency Attenuates the Development of Skin Fibrosis in Tight-Skin Mice"],"prefix":"10.1093","volume":"179","author":[{"given":"Yukiyo","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayuka","family":"Horikawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Kawasuji","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihide","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nagasaki University Graduate School of Biomedical Science , Nagasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A","family":"Steeber","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Wisconsin , Milwaukee, WI 53201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Tedder","sequence":"additional","affiliation":[{"name":"Department of Immunology, Duke University Medical Center , Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Takehara","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kanazawa University Graduate School of Medical Science , Kanazawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Nagasaki University Graduate School of Biomedical Science , Nagasaki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"2025032701445844700_R1","first-page":"1123","volume-title":"Mol. 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