{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:16:44Z","timestamp":1792084604290,"version":"4.4.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Productive HIV replication in the CNS occurs very early after infection, yet HIV-associated cognitive disorders do not typically manifest until the development of AIDS, suggesting that mechanisms exist in the CNS to control HIV replication and associated virus-induced pathological changes during the acute and asymptomatic stages of disease. Using an established SIV\/macaque model of HIV dementia, we recently demonstrated that the mechanisms regulating virus replication in the brain at these stages involve the production of IFN\u03b2, which induces the truncated, dominant-negative isoform of C\/EBP\u03b2, also referred to as LIP (liver-enriched transcriptional inhibitory protein). Alternative translation of C\/EBP\u03b2 mRNA and increased production of LIP can be mediated by CUGBP1 (CUG-repeat RNA-binding protein 1). Because IFN\u03b2 induces the inhibitory C\/EBP\u03b2 in macrophages, we considered the possibility that IFN\u03b2 signaling regulates the activity of CUGBP1, resulting in increased expression of LIP and suppression of SIV replication. In this study, we report that IFN\u03b2 induces LIP and suppresses active SIV replication in primary macrophages from rhesus macaques. Further, we demonstrate that IFN\u03b2 induces the phosphorylation of CUGBP1 and the formation of CUGBP1-C\/EBP\u03b2 mRNA complexes in the human monocytic U937 cell line. Finally, we demonstrate that CUGBP1 is not only required for IFN\u03b2-mediated induction of LIP but also for IFN\u03b2-mediated suppression of SIV replication. These results suggest that CUGBP1 is a previously unrecognized downstream effector of IFN\u03b2 signaling in primary macrophages that likely plays a pivotal role in innate immune responses that control acute HIV\/SIV replication in the brain.<\/jats:p>","DOI":"10.4049\/jimmunol.179.11.7262","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:01:40Z","timestamp":1397847700000},"page":"7262-7269","source":"Crossref","is-referenced-by-count":28,"title":["CUGBP1 Is Required for IFN\u03b2-Mediated Induction of Dominant-Negative CEBP\u03b2 and Suppression of SIV Replication in Macrophages"],"prefix":"10.1093","volume":"179","author":[{"given":"Justyna M","family":"Dudaronek","sequence":"first","affiliation":[{"name":"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila A","family":"Barber","sequence":"additional","affiliation":[{"name":"Booz Allen Hamilton , Rockville, MD 20852"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice E","family":"Clements","sequence":"additional","affiliation":[{"name":"Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2026012809303114500_R1","first-page":"493","volume-title":"Nat. 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