{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:18:14Z","timestamp":1791310694710,"version":"4.3.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>BAFF plays a central role in B-lineage cell biology; however, the regulation of BAFF-binding receptor (BBR) expression during B cell activation and differentiation is not completely understood. In this study, we provide a comprehensive ex vivo analysis of BBRs in human B-lineage cells at various stages of maturation, as well as describe the events that drive and regulate receptor expression. Our data reveal that B-lineage cells ranging from naive to plasma cells (PCs), excluding bone marrow PCs, express BAFF-R uniformly. In contrast, only tonsillar memory B cells (MB) and PCs, from both tonsil and bone marrow tissues, express BCMA. Furthermore, we show that TACI is expressed by MB cells and PCs, as well as a subpopulation of activated CD27neg B cells. In this regard, we demonstrate that TACI is inducible early upon B cell activation and this is independent of B cell turnover. In addition, we found that TACI expression requires activation of the ERK1\/2 pathway, since its expression was blocked by ERK1\/2-specific inhibitors. Expression of BAFF-R and B cell maturation Ag (BCMA) is also highly regulated and we demonstrate that BCMA expression is only acquired in MB cells and in a manner accompanied by loss of BAFF-R expression. This inverse expression coincides with MB cell differentiation into Ig-secreting cells (ISC), since blocking differentiation inhibited both induction of BCMA expression and loss of BAFF-R. Collectively, our data suggest that the BBR profile may serve as a footprint of the activation history and stage of differentiation of normal human B cells.<\/jats:p>","DOI":"10.4049\/jimmunol.179.11.7276","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:01:40Z","timestamp":1397847700000},"page":"7276-7286","source":"Crossref","is-referenced-by-count":245,"title":["Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation"],"prefix":"10.1093","volume":"179","author":[{"given":"Jaime R","family":"Darce","sequence":"first","affiliation":[{"name":"Department of Immunology, Mayo Clinic College of Medicine, Mayo Graduate School , Rochester MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie K","family":"Arendt","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic College of Medicine, Mayo Graduate School , Rochester MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic College of Medicine, Mayo Graduate School , Rochester MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane F","family":"Jelinek","sequence":"additional","affiliation":[{"name":"Department of Immunology, Mayo Clinic College of Medicine, Mayo Graduate School , Rochester MN 55905"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2026012809334072600_R1","first-page":"2111","volume-title":"Science","year":"2001"},{"key":"2026012809334072600_R2","first-page":"2108","volume-title":"Science","year":"2001"},{"key":"2026012809334072600_R3","first-page":"1697","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026012809334072600_R4","first-page":"3370","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2000"},{"key":"2026012809334072600_R5","first-page":"1919","volume-title":"Biochemistry","year":"2005"},{"key":"2026012809334072600_R6","first-page":"1986","volume-title":"Curr. Biol.","year":"2001"},{"key":"2026012809334072600_R7","first-page":"1547","volume-title":"Curr. Biol.","year":"2001"},{"key":"2026012809334072600_R8","first-page":"2331","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012809334072600_R9","first-page":"2245","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012809334072600_R10","first-page":"995","volume-title":"Nature","year":"2000"},{"key":"2026012809334072600_R11","first-page":"137","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026012809334072600_R12","first-page":"37","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026012809334072600_R13","first-page":"129","volume-title":"J. Exp. Med.","year":"2000"},{"key":"2026012809334072600_R14","first-page":"7218","volume-title":"J. Biol. Chem.","year":"2005"},{"key":"2026012809334072600_R15","first-page":"573","volume-title":"Immunity","year":"2001"},{"key":"2026012809334072600_R16","first-page":"279","volume-title":"Immunity","year":"2003"},{"key":"2026012809334072600_R17","first-page":"3235","volume-title":"Blood","year":"2006"},{"key":"2026012809334072600_R18","first-page":"35","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026012809334072600_R19","first-page":"820","volume-title":"Nat. Genet.","year":"2005"},{"key":"2026012809334072600_R20","first-page":"829","volume-title":"Nat. Genet.","year":"2005"},{"key":"2026012809334072600_R21","first-page":"2282","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012809334072600_R22","first-page":"1785","volume-title":"Eur. J. Immunol.","year":"2007"},{"key":"2026012809334072600_R23","first-page":"885","volume-title":"J. Allergy Clin. Immunol.","year":"2007"},{"key":"2026012809334072600_R24","first-page":"110","volume-title":"Eur. J. Immunol.","year":"2007"},{"key":"2026012809334072600_R25","first-page":"689","volume-title":"Blood","year":"2004"},{"key":"2026012809334072600_R26","first-page":"729","volume-title":"Blood","year":"2006"},{"key":"2026012809334072600_R27","first-page":"91","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026012809334072600_R28","first-page":"286","volume-title":"J. Clin. Invest.","year":"2003"},{"key":"2026012809334072600_R29","first-page":"807","volume-title":"J. Immunol.","year":"2004"},{"key":"2026012809334072600_R30","first-page":"779","volume-title":"Int. Immunol.","year":"2005"},{"key":"2026012809334072600_R31","first-page":"7531","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012809334072600_R32","first-page":"5612","volume-title":"J. Immunol.","year":"2007"},{"key":"2026012809334072600_R33","first-page":"577","volume-title":"Int. Immunol.","year":"2003"},{"key":"2026012809334072600_R34","first-page":"594","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2026012809334072600_R35","first-page":"3274","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2006"},{"key":"2026012809334072600_R36","first-page":"4034","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012809334072600_R37","first-page":"2401","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1978"},{"key":"2026012809334072600_R38","first-page":"1306","volume-title":"J. Immunol.","year":"1983"},{"key":"2026012809334072600_R39","first-page":"192","volume-title":"J. Immunol.","year":"1985"},{"key":"2026012809334072600_R40","first-page":"4390","volume-title":"Blood","year":"2005"},{"key":"2026012809334072600_R41","first-page":"822","volume-title":"Nat. Rev. Immunol.","year":"2003"},{"key":"2026012809334072600_R42","first-page":"593","volume-title":"Blood","year":"2005"},{"key":"2026012809334072600_R43","first-page":"3967","volume-title":"Blood","year":"2006"},{"key":"2026012809334072600_R44","first-page":"2545","volume-title":"Blood","year":"2007"},{"key":"2026012809334072600_R45","first-page":"854","volume-title":"Br. J. Haematol.","year":"2001"},{"key":"2026012809334072600_R46","first-page":"217","volume-title":"Med. Oncol.","year":"2005"},{"key":"2026012809334072600_R47","first-page":"1021","volume-title":"Blood","year":"2005"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/179\/11\/7276\/62666138\/zim02307007276.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/179\/11\/7276\/62666138\/zim02307007276.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:33:49Z","timestamp":1769610829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/179\/11\/7276\/8022488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,1]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2007,12,1]]},"published-print":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.179.11.7276","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,12]]},"published":{"date-parts":[[2007,12,1]]}}}