{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:27:29Z","timestamp":1790400449190,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>NK cells can identify and eliminate emerging tumors due to altered expression of activating and inhibitory ligands on aberrant cells, a process that is greatly enhanced following NK cell activation. As a principal site of both tumor metastases and immature NK cells, the liver represents a unique anatomic location in which activation of the innate immune system could provide substantial therapeutic benefit. We describe here the NK cell-dependent destruction of a primary hepatic tumor following infection with an attenuated intracellular bacterium derived from Listeria monocytogenes. NK cell-mediated immunity correlated with the ordered migration and maturation of NK cells within the liver. Cytolytic activity was partially dependent on NKG2D-mediated tumor cell recognition, but surprisingly was still effective in the absence of type I IFN. Significantly, NK cell-mediated destruction of a primary hepatic tumor in infected mice led to long-lived CD4- and CD8 T cell-dependent tumor-specific adaptive immunity. These findings establish that activation and differentiation of immature NK cells using complex microbial stimuli can elicit potent anti-tumor activity within the liver, promote cross-presentation of tumor-derived Ags leading to long-lived systemic anti-tumor immunity, and suggests a paradigm for clinical intervention of liver metastatic carcinoma.<\/jats:p>","DOI":"10.4049\/jimmunol.179.11.7376","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:01:40Z","timestamp":1397847700000},"page":"7376-7384","source":"Crossref","is-referenced-by-count":22,"title":["Activation of Immature Hepatic NK Cells As Immunotherapy for Liver Metastatic Disease"],"prefix":"10.1093","volume":"179","author":[{"given":"Keith S","family":"Bahjat","sequence":"first","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney A","family":"Prell","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather E","family":"Allen","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqun","family":"Liu","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward E","family":"Lemmens","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith L","family":"Leong","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A","family":"Portnoy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California , Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Thomas W","family":"Dubensky","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk G","family":"Brockstedt","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin A","family":"Giedlin","sequence":"additional","affiliation":[{"name":"Cerus Corporation , Concord, CA 94520"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2026012809352806300_R1","first-page":"374","volume-title":"Curr. Opin. Microbiol.","year":"1999"},{"key":"2026012809352806300_R2","first-page":"219","volume-title":"Immunol. Rev.","year":"2006"},{"key":"2026012809352806300_R3","first-page":"225","volume-title":"Annu. Rev. Immunol.","year":"2005"},{"key":"2026012809352806300_R4","first-page":"661","volume-title":"Cell","year":"1997"},{"key":"2026012809352806300_R5","first-page":"523","volume-title":"Nat. Immunol.","year":"2002"},{"key":"2026012809352806300_R6","first-page":"2082","volume-title":"Blood","year":"2005"},{"key":"2026012809352806300_R7","first-page":"405","volume-title":"Annu. Rev. Immunol.","year":"2004"},{"key":"2026012809352806300_R8","first-page":"1356","volume-title":"J. Immunol.","year":"2002"},{"key":"2026012809352806300_R9","first-page":"3042","volume-title":"Front. Biosci.","year":"2005"},{"key":"2026012809352806300_R10","first-page":"466","volume-title":"Am. Surg.","year":"2006"},{"key":"2026012809352806300_R11","first-page":"149","volume-title":"J. Exp. Clin. Cancer Res.","year":"2003"},{"key":"2026012809352806300_R12","first-page":"1069","volume-title":"Hepatogastroenterology","year":"1997"},{"key":"2026012809352806300_R13","first-page":"1237","volume-title":"Br. J. Surg.","year":"1999"},{"key":"2026012809352806300_R14","first-page":"176","volume-title":"Am. J. Surg.","year":"1992"},{"key":"2026012809352806300_R15","first-page":"776","volume-title":"Am. J. Surg.","year":"1993"},{"key":"2026012809352806300_R16","first-page":"145","volume-title":"Am. J. Med. Sci.","year":"1957"},{"key":"2026012809352806300_R17","first-page":"137","volume-title":"Am. J. Pathol.","year":"1942"},{"key":"2026012809352806300_R18","first-page":"148","volume-title":"J. Surg. Res.","year":"1998"},{"key":"2026012809352806300_R19","first-page":"529","volume-title":"Am. J. Surg.","year":"2001"},{"key":"2026012809352806300_R20","first-page":"279","volume-title":"Am. J. Surg.","year":"1999"},{"key":"2026012809352806300_R21","first-page":"275","volume-title":"Annu. Rev. Immunol.","year":"2000"},{"key":"2026012809352806300_R22","first-page":"812","volume-title":"Nat. Rev. Immunol.","year":"2004"},{"key":"2026012809352806300_R23","first-page":"11","volume-title":"Immunol. Rev.","year":"1997"},{"key":"2026012809352806300_R24","first-page":"13832","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2004"},{"key":"2026012809352806300_R25","first-page":"423","volume-title":"Nat. Rev. Microbiol.","year":"2006"},{"key":"2026012809352806300_R26","first-page":"1263","volume-title":"Infect. Immun.","year":"1992"},{"key":"2026012809352806300_R27","first-page":"13861","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2026012809352806300_R28","first-page":"891","volume-title":"Immunity","year":"2003"},{"key":"2026012809352806300_R29","first-page":"701","volume-title":"Immunity","year":"2003"},{"key":"2026012809352806300_R30","first-page":"527","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026012809352806300_R31","first-page":"2434","volume-title":"Cancer Res.","year":"1975"},{"key":"2026012809352806300_R32","first-page":"810","volume-title":"Ann. Surg. Oncol.","year":"2003"},{"key":"2026012809352806300_R33","first-page":"4177","volume-title":"J. Bacteriol.","year":"2002"},{"key":"2026012809352806300_R34","first-page":"192","volume-title":"Blood","year":"2001"},{"key":"2026012809352806300_R35","first-page":"1096","volume-title":"Cancer Res.","year":"2006"},{"key":"2026012809352806300_R36","first-page":"119","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2026012809352806300_R37","first-page":"583","volume-title":"J. Exp. Med.","year":"2005"},{"key":"2026012809352806300_R38","first-page":"4746","volume-title":"J. Immunol.","year":"1996"},{"key":"2026012809352806300_R39","first-page":"1549","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012809352806300_R40","first-page":"189","volume-title":"Annu. Rev. Immunol.","year":"1999"},{"key":"2026012809352806300_R41","first-page":"93","volume-title":"Immunity","year":"2006"},{"key":"2026012809352806300_R42","first-page":"3571","volume-title":"J. Immunol.","year":"2000"},{"key":"2026012809352806300_R43","first-page":"321","volume-title":"J. Clin. Invest.","year":"2002"},{"key":"2026012809352806300_R44","first-page":"1325","volume-title":"J. Exp. Med.","year":"2004"},{"key":"2026012809352806300_R45","first-page":"343","volume-title":"J. Exp. Med.","year":"2001"},{"key":"2026012809352806300_R46","first-page":"634","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1997"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/179\/11\/7376\/62668862\/zim02307007376.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/179\/11\/7376\/62668862\/zim02307007376.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:35:34Z","timestamp":1769610934000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/179\/11\/7376\/8022557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,1]]},"references-count":46,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2007,12,1]]},"published-print":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.179.11.7376","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,12]]},"published":{"date-parts":[[2007,12,1]]}}}