{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:01:45Z","timestamp":1791842505757,"version":"4.3.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The noncanonical NF-\u03baB pathway regulates the development and function of multiple organs and cell lineages. We have generated mice harboring a novel mutation in Nfkb2 that prevents the processing of the inhibitory precursor, p100, into the active subunit, p52. Mutant mice express a complex phenotype with abnormalities in a variety of tissues, and with a spectrum that is more severe than in mice carrying a targeted deletion of Nfkb2. Signaling through the noncanonical pathway is ablated due to the absence of p52, resulting in disorganized splenic architecture and disrupted B cell development. The inhibitory precursor form of NF-\u03baB2 interacts with RelA, preventing activation of RelA dimers in response to both canonical and noncanonical stimuli, which in combination with p52 deficiency, results in defective lymph node formation and bone homeostasis. These findings demonstrate a key role for NF-\u03baB2 in the regulation of RelA activation and suggest overlap in the function of NF-\u03baB members in canonical and noncanonical pathway signaling.<\/jats:p>","DOI":"10.4049\/jimmunol.179.11.7514","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:01:40Z","timestamp":1397847700000},"page":"7514-7522","source":"Crossref","is-referenced-by-count":77,"title":["A Novel Mutation in the\n                    <i>Nfkb2<\/i>\n                    Gene Generates an NF-\u03baB2 \u201cSuper Repressor\u201d"],"prefix":"10.1093","volume":"179","author":[{"given":"Elena","family":"Tucker","sequence":"first","affiliation":[{"name":"St. Vincent\u2019s Institute , Fitzroy, Victoria ,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristy","family":"O\u2019Donnell","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Fuchsberger","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute , Fitzroy, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne A","family":"Hilton","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Metcalf","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Greig","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie A","family":"Sims","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute , Fitzroy, Victoria ,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian M","family":"Quinn","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute , Fitzroy, Victoria ,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren S","family":"Alexander","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]},{"name":"Department of Medical Biology, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas J","family":"Hilton","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]},{"name":"Department of Medical Biology, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin T","family":"Kile","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]},{"name":"Department of Medical Biology, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Tarlinton","sequence":"additional","affiliation":[{"name":"The Walter and Eliza Hall Institute, University of Melbourne , Parkville, Victoria ,","place":["Australia"]},{"name":"Department of Medical Biology, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Starr","sequence":"additional","affiliation":[{"name":"St. Vincent\u2019s Institute , Fitzroy, Victoria ,","place":["Australia"]},{"name":"Department of Medicine, University of Melbourne , Parkville, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2026012809353416400_R1","first-page":"393","volume-title":"Biochem. 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