{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T09:30:44Z","timestamp":1771666244868,"version":"3.50.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A single intradermal injection of the mineral oil pristane in susceptible DA.1F rats induces erosive arthritis closely mimicking rheumatoid arthritis (RA). Pristane-induced arthritis (PIA) is driven by autoreactive T cells but no autoantigen has been identified to date. We therefore analyzed B and T cell responses to autoantigens potentially involved in the pathogenesis of RA, including IgG, citrullinated proteins, stress proteins, glucose-6-phosphate isomerase, and heterogeneous nuclear ribonucleoprotein (hnRNP)-A2 (RA33). IgG and IgM autoantibodies to hnRNP-A2 were detectable in sera of pristane-primed DA.1F rats already 1 wk before disease onset, reached maximum levels during the acute phase, and correlated with arthritis severity. Apart from rheumatoid factor, autoantibodies to other Ags were not observed. CD4+ lymph node cells isolated 10 days after pristane injection produced IFN-\u03b3 but not IL-4 in response to stimulation with hnRNP-A2, whereas none of the other candidate Ags elicited cytokine secretion. Surprisingly, hnRNP-A2 also stimulated lymph node cells of naive animals to produce inflammatory cytokines in a MyD88-dependent manner. Furthermore, hnRNP-A2 was highly overexpressed in the joints of rats injected with pristane. Overexpression coincided with the appearance of anti-RA33 Abs and preceded the onset of clinical symptoms of PIA by several days. Taken together, these data suggest hnRNP-A2 to be among the primary inducers of autoimmunity in PIA. Therefore, this Ag might play a pivotal role in the pathogenesis of PIA and possibly also human RA.<\/jats:p>","DOI":"10.4049\/jimmunol.179.11.7568","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:01:40Z","timestamp":1397847700000},"page":"7568-7576","source":"Crossref","is-referenced-by-count":51,"title":["The Rheumatoid Arthritis-Associated Autoantigen hnRNP-A2 (RA33) Is a Major Stimulator of Autoimmunity in Rats with Pristane-Induced Arthritis"],"prefix":"10.1093","volume":"179","author":[{"given":"Markus H","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Medical University of Vienna , Vienna ,","place":["Austria"]},{"name":"Center of Molecular Medicine of the Austrian Academy of Sciences , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatan","family":"Tuncel","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Section for Medical Inflammation Research , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Skriner","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Charite\u0301 University Hospital , Berlin ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiyeh","family":"Tohidast-Akrad","sequence":"additional","affiliation":[{"name":"Ludwig Boltzmann Institute for Rheumatology and Balneology, Second Department of Medicine, Hietzing Hospital , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Tu\u0308rk","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serafin","family":"Pinol-Roma","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomical Sciences, Sophie Davis School of Biomedical Education\/City University of New York Medical School , New York, NY 10031"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Serre","sequence":"additional","affiliation":[{"name":"Laboratory of Epidermis Differentiation and Rheumatoid Autoimmunity, Centre National de la Recherche Scientifique-Toulouse III University , Toulouse ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef S","family":"Smolen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Medical University of Vienna , Vienna ,","place":["Austria"]},{"name":"Center of Molecular Medicine of the Austrian Academy of Sciences , Vienna ,","place":["Austria"]},{"name":"Ludwig Boltzmann Institute for Rheumatology and Balneology, Second Department of Medicine, Hietzing Hospital , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikard","family":"Holmdahl","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, Section for Medical Inflammation Research , Lund ,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gu\u0308nter","family":"Steiner","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Medical University of Vienna , Vienna ,","place":["Austria"]},{"name":"Center of Molecular Medicine of the Austrian Academy of Sciences , Vienna ,","place":["Austria"]},{"name":"Ludwig Boltzmann Institute for Rheumatology and Balneology, Second Department of Medicine, Hietzing Hospital , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2026012809283129200_R1","first-page":"380","volume-title":"Arthritis Rheum.","year":"2004"},{"key":"2026012809283129200_R2","first-page":"2741","volume-title":"Arthritis Rheum.","year":"2003"},{"key":"2026012809283129200_R3","first-page":"1675","volume-title":"Am. 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