{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:54:27Z","timestamp":1790636067929,"version":"4.1.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polymorphisms in Fc\u03b3R genes are associated with susceptibility to or severity of a number of autoimmune and infectious diseases. We found that HIV-infected men in the Multicenter AIDS Cohort Study with the Fc\u03b3RIIa RR genotype progressed to a CD4+ cell count of &amp;lt;200\/mm3 at a faster rate than individuals with the RH or HH genotypes (relative hazard = 1.6; p = 0.0001). However, progression to AIDS (using the broad definition of either a CD4+ cell count &amp;lt;200\/mm3 or development of an AIDS-defining illness) was less impacted by Fc\u03b3RIIa genotype, largely because HH homozygotes had an increased risk of Pneumocystis jiroveci pneumonia as an AIDS-defining illness. We also showed that chronically infected subjects develop a substantial anti-gp120-specific IgG2 response. Moreover, HIV-1 immune complexes are more efficiently internalized by monocytes from HH subjects compared with RR subjects, likely because of the presence of IgG2 in the complexes. Finally, the Fc\u03b3RIIIa F\/V gene polymorphism was not associated with progression of HIV infection, but, as demonstrated previously, did predict the risk of Kaposi\u2019s sarcoma. These results demonstrate the importance of Fc\u03b3Rs in AIDS pathogenesis and point toward a critical role for interactions between Fc\u03b3Rs and immune complexes in disease progression.<\/jats:p>","DOI":"10.4049\/jimmunol.179.11.7916","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:01:40Z","timestamp":1397847700000},"page":"7916-7923","source":"Crossref","is-referenced-by-count":120,"title":["Fc\u03b3RIIa Genotype Predicts Progression of HIV Infection"],"prefix":"10.1093","volume":"179","author":[{"given":"Donald N","family":"Forthal","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine , Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Landucci","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine , Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Bream","sequence":"additional","affiliation":[{"name":"Disease Prevention and Control Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa P","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran B","family":"Phan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine , Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Montoya","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine , Irvine, CA 92697"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,1]]},"reference":[{"key":"2026012809295010000_R1","first-page":"515","volume-title":"Clin. 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