{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T14:28:37Z","timestamp":1789914517763,"version":"4.0.1"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Genetic studies of human susceptibility to Schistosoma (blood fluke) infections have previously identified a genetic locus determining infection intensity with the African species, Schistosoma mansoni, in the 5q31\u201333 region of the human genome that is known to contain the Th2 immune response cluster, including the genes encoding the IL-4, IL-5, and IL-13 cytokines. These cytokines are key players in inflammatory immune responses and have previously been implicated in human susceptibility to infection with the Asian species, S. japonicum. In a nested case control study, we genotyped 30 HapMap tagging single nucleotide polymorphisms (SNPs) across these three genes in 159 individuals identified as putatively susceptible to reinfection with S. japonicum and in 133 putatively resistant individuals. A third group comprising 113 individuals demonstrating symptomatic infection was also included. The results provided no significant association at a global level between reinfection predisposition and any of the individual SNPs or haplotype blocks. However, two tagging SNPs in IL-5 demonstrated globally significant association with susceptibility to symptomatic infection. They were in strong linkage disequilibrium with each other and were found to belong to the same haplotype block that also provided a significant association after permutation testing. This haplotype was located in the 3\u2032-untranslated region of IL-5, suggesting that variants in this region of IL-5 may modulate the immune response in these individuals with symptomatic infection.<\/jats:p>","DOI":"10.4049\/jimmunol.179.12.8366","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:25:48Z","timestamp":1397849148000},"page":"8366-8371","source":"Crossref","is-referenced-by-count":23,"title":["Analysis of the 5q31\u201333 Locus Shows an Association between Single Nucleotide Polymorphism Variants in the\n                    <i>IL-5<\/i>\n                    Gene and Symptomatic Infection with the Human Blood Fluke,\n                    <i>Schistosoma japonicum<\/i>"],"prefix":"10.1093","volume":"179","author":[{"given":"Magda K","family":"Ellis","sequence":"first","affiliation":[{"name":"Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen Zhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Laboratories, Queensland Institute of Medical Research , Brisbane ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Gen","family":"Chen","sequence":"additional","affiliation":[{"name":"Jiangxi Provincial Institute of Parasitic Diseases , Nanchang ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W","family":"Montgomery","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Laboratories, Queensland Institute of Medical Research , Brisbane ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Sheng","family":"Li","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland ,","place":["Australia"]},{"name":"Hunan Institute of Parasitic Diseases, World Health Organization Collaborating Centre for Research and Control on Schistosomiasis in Lake Region , Yueyang, Hunan Province ,","place":["People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P","family":"McManus","sequence":"additional","affiliation":[{"name":"Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, Queensland Institute of Medical Research and University of Queensland ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,12,15]]},"reference":[{"key":"2026012809281240700_R1","first-page":"161","volume-title":"Chin. J. Schisto. Contr.","year":"2005"},{"key":"2026012809281240700_R2","first-page":"218","volume-title":"Lancet Infect. Dis.","year":"2007"},{"key":"2026012809281240700_R3","first-page":"127","volume-title":"Acta Trop.","year":"2002"},{"key":"2026012809281240700_R4","first-page":"71","volume-title":"Int. J. Parasitol.","year":"2006"},{"key":"2026012809281240700_R5","first-page":"49","volume-title":"Mem. Inst. Oswaldo Cruz","year":"2001"},{"key":"2026012809281240700_R6","first-page":"336","volume-title":"Am. J. Trop. Med. Hyg.","year":"2002"},{"key":"2026012809281240700_R7","first-page":"959","volume-title":"Am. J. Hum Genet.","year":"1991"},{"key":"2026012809281240700_R8","first-page":"88","volume-title":"Eur. J. Hum. Genet.","year":"1999"},{"key":"2026012809281240700_R9","first-page":"181","volume-title":"Nat. Genet.","year":"1996"},{"key":"2026012809281240700_R10","first-page":"452","volume-title":"Am. J. Hum. Genet.","year":"1997"},{"key":"2026012809281240700_R11","first-page":"505","volume-title":"Annu. Rev. Immunol.","year":"1997"},{"key":"2026012809281240700_R12","first-page":"269","volume-title":"Trends Immunol\/","year":"2003"},{"key":"2026012809281240700_R13","first-page":"1207","volume-title":"J. Infect. Dis.","year":"2000"},{"key":"2026012809281240700_R14","first-page":"1804","volume-title":"J. Infect. Dis.","year":"2004"},{"key":"2026012809281240700_R15","first-page":"1237","volume-title":"Int. J. Parasitol.","year":"2004"},{"key":"2026012809281240700_R16","first-page":"430","volume-title":"J. Infect. Dis.","year":"2004"},{"key":"2026012809281240700_R17","first-page":"1768","volume-title":"J. Infect. Dis.","year":"2003"},{"key":"2026012809281240700_R18","first-page":"117","volume-title":"Acta Trop.","year":"2003"},{"key":"2026012809281240700_R19","first-page":"370","volume-title":"Infect. Immun.","year":"2006"},{"key":"2026012809281240700_R20","first-page":"6274","volume-title":"J. Immunol.","year":"2005"},{"key":"2026012809281240700_R21","first-page":"302","volume-title":"Am. J. Trop. Med. Hyg.","year":"1997"},{"key":"2026012809281240700_R22","first-page":"1505","volume-title":"Am. J. Hum. Genet.","year":"2003"},{"key":"2026012809281240700_R23","first-page":"385","volume-title":"Genes Immun.","year":"2003"},{"key":"2026012809281240700_R24","first-page":"528","volume-title":"Genes Immun.","year":"2003"},{"key":"2026012809281240700_R25","first-page":"387","volume-title":"Hum. Genet.","year":"2003"},{"key":"2026012809281240700_R26","first-page":"728","volume-title":"Nephrol. Dial. Transplant.","year":"2005"},{"key":"2026012809281240700_R27","first-page":"263","volume-title":"Bioinformatics","year":"2005"},{"key":"2026012809281240700_R28","first-page":"2225","volume-title":"Science","year":"2002"},{"key":"2026012809281240700_R29","first-page":"8","volume-title":"BMC Immunol.","year":"2002"},{"key":"2026012809281240700_R30","first-page":"371","volume-title":"Parasite Immunol.","year":"2004"},{"key":"2026012809281240700_R31","first-page":"1565","volume-title":"J. Exp. Med.","year":"1999"},{"key":"2026012809281240700_R32","first-page":"855","volume-title":"J. Allergy Clin. Immunol.","year":"2007"},{"key":"2026012809281240700_R33","first-page":"B2","volume-title":"Nature","year":"1999"},{"key":"2026012809281240700_R34","first-page":"423","volume-title":"Allergy","year":"2007"},{"key":"2026012809281240700_R35","first-page":"42","volume-title":"Respirology","year":"2007"},{"key":"2026012809281240700_R36","first-page":"9","volume-title":"Iran J. Allergy Asthma Immunol.","year":"2007"},{"key":"2026012809281240700_R37","first-page":"206","volume-title":"Int. Arch. Allergy Immunol.","year":"2004"},{"key":"2026012809281240700_R38","first-page":"449","volume-title":"Clin. Exp. Allergy","year":"1998"},{"key":"2026012809281240700_R39","first-page":"1306","volume-title":"J. Allergy Clin. Immunol.","year":"2006"},{"key":"2026012809281240700_R40","first-page":"288","volume-title":"Pediatr. Allergy Immunol.","year":"2007"},{"key":"2026012809281240700_R41","first-page":"512","volume-title":"J. Infect. Dis.","year":"1998"},{"key":"2026012809281240700_R42","first-page":"4689","volume-title":"Infect. Immun.","year":"1999"},{"key":"2026012809281240700_R43","first-page":"9","volume-title":"J. Travel Med.","year":"2005"},{"key":"2026012809281240700_R44","first-page":"98","volume-title":"J. Infect. Dis.","year":"2002"},{"key":"2026012809281240700_R45","first-page":"429","volume-title":"Parasite Immunol.","year":"2004"},{"key":"2026012809281240700_R46","first-page":"1722","volume-title":"Hum. Mol. Genet.","year":"2006"},{"key":"2026012809281240700_R47","first-page":"857","volume-title":"J. Med. Genet.","year":"2005"},{"key":"2026012809281240700_R48","first-page":"361","volume-title":"J. Endocrinol.","year":"1998"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/179\/12\/8366\/62667011\/zim02407008366.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/179\/12\/8366\/62667011\/zim02407008366.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:28:23Z","timestamp":1769610503000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/179\/12\/8366\/8022191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2007,12,15]]},"published-print":{"date-parts":[[2007,12,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.179.12.8366","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,12]]},"published":{"date-parts":[[2007,12]]}}}