{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:16:09Z","timestamp":1776262569941,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Src homology 2 domain-containing protein tyrosine phosphatase (SHP) substrate-1 (SHPS-1) is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is expressed on the surface of CD11c+ dendritic cells (DCs) and macrophages. In this study, we show that mice that express a mutant form of SHPS-1 lacking most of the cytoplasmic region are resistant to experimental autoimmune encephalomyelitis (EAE) in response to immunization with a peptide derived from myelin oligodendrocyte glycoprotein (MOG (35\u201355)). The MOG (35\u201355)-induced proliferation of, and production of IFN-\u03b3, IL-2, and IL-17, by T cells from immunized SHPS-1 mutant mice were reduced compared with those apparent for wild-type cells. The abilities of splenic DCs from mutant mice to stimulate an allogenic MLR and to prime Ag-specific T cells were reduced. Both IL-12-stimulated and TLR-dependent cytokine production by DCs of mutant mice were also impaired. Finally, SHPS-1 mutant mice were resistant to induction of EAE by adoptive transfer of MOG (35\u201355)-specific T cells. These results show that SHPS-1 on DCs is essential for priming of naive T cells and the development of EAE. SHPS-1 is thus a potential therapeutic target in inflammatory disorders of the CNS and other autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.179.2.869","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:08:33Z","timestamp":1397862513000},"page":"869-877","source":"Crossref","is-referenced-by-count":49,"title":["Resistance to Experimental Autoimmune Encephalomyelitis and Impaired T Cell Priming by Dendritic Cells in Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 Mutant Mice"],"prefix":"10.1093","volume":"179","author":[{"given":"Takeshi","family":"Tomizawa","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University , Gunma ,","place":["Japan"]},{"name":"Department of Neurology, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoriaki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ohnishi","sequence":"additional","affiliation":[{"name":"Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Okajo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chie","family":"Okuzawa","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Ishikawa-Sekigami","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoji","family":"Murata","sequence":"additional","affiliation":[{"name":"Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Okazawa","sequence":"additional","affiliation":[{"name":"Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Nojima","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Gunma University Graduate School of Medicine , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Matozaki","sequence":"additional","affiliation":[{"name":"Laboratory of Biosignal Sciences, Institute for Molecular and Cellular Regulation, Gunma University , Gunma ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,7,15]]},"reference":[{"key":"2025032701452389000_R1","first-page":"245","volume-title":"Nature","year":"1998"},{"key":"2025032701452389000_R2","first-page":"199","volume-title":"Nat. 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