{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:06:34Z","timestamp":1791331594504,"version":"4.3.1"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Self-tolerance to melanocyte differentiation Ags limits the ability to generate therapeutic antimelanoma responses. However, the mechanisms responsible for CD8 T cell tolerance to these Ags are unknown. We have used a newly generated TCR-transgenic mouse to establish the basis of tolerance to one such Ag from tyrosinase. Despite expression of tyrosinase transcripts in the thymus, central deletion does not shape the tyrosinase-specific CD8 T cell repertoire. We demonstrate that this endogenously expressed melanocyte Ag is constitutively presented in both peripheral and mesenteric lymph nodes, leading to abortive activation and deletion of tyrosinase-specific CD8 T cells. Importantly, this Ag is not presented by either radio-sensitive dendritic cells, or by radio-resistant Langerhans cells. Thus, for this endogenous Ag, cross-tolerization does not appear to be an operative mechanism. Instead, we find radioresistant tyrosinase mRNA expression in lymphoid compartments where CD8 T cell deletion occurs. This suggests that direct presentation of tyrosinase by radio-resistant lymph node resident cells is entirely responsible for tolerance to this endogenous melanocyte differentiation Ag.<\/jats:p>","DOI":"10.4049\/jimmunol.179.2.993","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:08:33Z","timestamp":1397862513000},"page":"993-1003","source":"Crossref","is-referenced-by-count":130,"title":["Deletional Self-Tolerance to a Melanocyte\/Melanoma Antigen Derived from Tyrosinase Is Mediated by a Radio-Resistant Cell in Peripheral and Mesenteric Lymph Nodes"],"prefix":"10.1093","volume":"179","author":[{"given":"Lisa A","family":"Nichols","sequence":"first","affiliation":[{"name":"Department of Microbiology and Carter Immunology Center, University of Virginia Health System , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Carter Immunology Center, University of Virginia Health System , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa A","family":"Colella","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Carter Immunology Center, University of Virginia Health System , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare L","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjo\u0308rn E","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam , Amsterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor H","family":"Engelhard","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Carter Immunology Center, University of Virginia Health System , Charlottesville, VA 22908"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,7,15]]},"reference":[{"key":"2025032701451865100_R1","first-page":"136","volume-title":"Immunol. 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