{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:38:02Z","timestamp":1791459482912,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It is well recognized that IFN-\u03b3 plays a critical role in the control of CD8 T cell expansion and contraction during immune responses to several intracellular pathogens. However, our understanding of the mechanisms underlying the regulation of T cell fate by IFN-\u03b3 is sorely incomplete. Specifically, it is unclear whether regulation of CD8 T cell homeostasis occurs by a T cell intrinsic IFN-\u03b3 pathway. In this study, we have determined the role of the direct effects of IFN-\u03b3 on T cells in regulating the expansion, contraction, and memory phases of the polyclonal CD8 T cell response to an acute viral infection. Using two complementary approaches we demonstrate that the direct effects of IFN-\u03b3 suppress IL-7R expression on Ag-specific effector CD8 T cells, but clonal expansion or deletion of activated CD8 T cells in vivo can occur in the apparent absence of IFN-\u03b3R signaling in T cells. These findings have clarified fundamental features of control of T cell homeostasis by IFN-\u03b3 in the context of CD8 T cell memory and protective immunity.<\/jats:p>","DOI":"10.4049\/jimmunol.179.4.2115","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:56:09Z","timestamp":1397847369000},"page":"2115-2125","source":"Crossref","is-referenced-by-count":74,"title":["Role of Direct Effects of IFN-\u03b3 on T Cells in the Regulation of CD8 T Cell Homeostasis"],"prefix":"10.1093","volume":"179","author":[{"given":"Kavita","family":"Tewari","sequence":"first","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Suresh","sequence":"additional","affiliation":[{"name":"Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,8,15]]},"reference":[{"key":"2026012809182235200_R1","first-page":"563","volume-title":"Annu. 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