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The aim of the present study was to investigate whether the NF-\u03baB essential modulator (NEMO)-binding domain (NBD) peptide, which has been shown to block the association of NEMO with the I\u03baB kinase\u03b2 subunit (IKK\u03b2) and inhibit NF-\u03baB activity, reduces inflammatory injury in mice with colitis. Two colitis models were established by the following: 1) inclusion of dextran sulfate sodium salt (DSS) in the drinking water of the mice; and 2) a trinitrobenzene sulfonic acid enema. Marked NF-\u03baB activation and expression of proinflammatory cytokines were observed in colonic tissues. The NBD peptide ameliorated colonic inflammatory injury through the down-regulation of proinflammatory cytokines mediated by NF-\u03baB inhibition in both models. These results indicate that an IKK\u03b2-targeted NF-\u03baB blockade using the NBD peptide could be an attractive therapeutic approach for inflammatory bowel disease.<\/jats:p>","DOI":"10.4049\/jimmunol.179.5.2681","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:17:46Z","timestamp":1397848666000},"page":"2681-2685","source":"Crossref","is-referenced-by-count":116,"title":["Cutting Edge: The I\u03baB Kinase (IKK) Inhibitor, NEMO-Binding Domain Peptide, Blocks Inflammatory Injury in Murine Colitis"],"prefix":"10.1093","volume":"179","author":[{"given":"Wataru","family":"Shibata","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation , Tokyo ,","place":["Japan"]},{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation , Tokyo ,","place":["Japan"]},{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohko","family":"Hikiba","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Yanai","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Institute for Adult Diseases, Asahi Life Foundation , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Ohmae","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Ogura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Omata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Tokyo , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,9,1]]},"reference":[{"key":"2026012809353407000_R1","first-page":"652","volume-title":"Trends Immunol.","year":"2003"},{"key":"2026012809353407000_R2","first-page":"182","volume-title":"Gastroenterology","year":"1998"},{"key":"2026012809353407000_R3","first-page":"417","volume-title":"N. 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