{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:27:57Z","timestamp":1787030877217,"version":"build-2736575974"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Evidence suggests a genetic predisposition to chronic beryllium disease (CBD) and sarcoidosis, which are clinically and pathologically similar granulomatous lung diseases. TGF-\u03b21, a cytokine involved in mediating the fibrotic\/Th1 response, has several genetic variants which might predispose individuals to these lung diseases. We examined whether certain TGF-\u03b21 variants and haplotypes are found at higher rates in CBD and sarcoidosis cases compared with controls and are associated with disease severity indicators for both diseases. Using DNA from sarcoidosis cases\/controls from A Case Control Etiologic Study of Sarcoidosis Group (ACCESS) and CBD cases\/controls, TGF-\u03b21 variants were analyzed by sequence-specific primer PCR. No significant differences were found between cases and controls for either disease in the TGF-\u03b21 variants or haplotypes. The \u2212509C and codon 10T were significantly associated with disease severity indicators in both CBD and sarcoidosis. Haplotypes that included the \u2212509C and codon 10T were also associated with more severe disease, whereas one or more copies of the haplotype containing the \u2212509T and codon 10C was protective against severe disease for both sarcoidosis and CBD. These studies suggest that the \u2212509C and codon 10T, implicated in lower levels of TGF-\u03b21 protein production, are shared susceptibility factors associated with more severe granulomatous disease in sarcoidosis and CBD. This association may be due to lack of down-regulation by TGF-\u03b21, although future studies will be needed to correlate TGF-\u03b21 protein levels with known TGF-\u03b21 genotypes and assess whether there is a shared mechanisms for TGF-\u03b21 in these two granulomatous diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.179.6.4255","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:32:36Z","timestamp":1397849556000},"page":"4255-4262","source":"Crossref","is-referenced-by-count":40,"title":["TGF-\u03b21 Variants in Chronic Beryllium Disease and Sarcoidosis"],"prefix":"10.1093","volume":"179","author":[{"given":"Alexas C","family":"Jonth","sequence":"first","affiliation":[{"name":"Robert H. Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Silveira","sequence":"additional","affiliation":[{"name":"Robert H. Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center , Denver, CO 80206"},{"name":"Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center , Denver, CO 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasha E","family":"Fingerlin","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center , Denver, CO 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroe","family":"Sato","sequence":"additional","affiliation":[{"name":"Robert H. Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center , Denver, CO 80206"},{"name":"Clinical Genomic Group, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie C","family":"Luby","sequence":"additional","affiliation":[{"name":"Robert H. Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center , Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth I","family":"Welsh","sequence":"additional","affiliation":[{"name":"Clinical Genomic Group, Royal Brompton Hospital and National Heart and Lung Institute, Imperial College of Science, Technology and Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile S","family":"Rose","sequence":"additional","affiliation":[{"name":"Robert H. Hollis Laboratory of Environmental and Occupational Health, Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Medical and Research Center , Denver, CO 80206"},{"name":"Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center , Denver, CO 80262"},{"name":"Division of Pulmonary and Critical Care Sciences, Department of Medicine, University of Colorado at Denver and Health Sciences Center , Denver, CO 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Biometrics, University of Colorado at Denver and Health Sciences Center , Denver, CO 80262"},{"name":"Division of Pulmonary and Critical Care Sciences, Department of Medicine, University of Colorado at Denver and Health Sciences Center , Denver, CO 80262"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland M","family":"du Bois","sequence":"additional","affiliation":[{"name":"Robert H. 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