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In this study, we show that advanced cutaneous T cell lymphoma (CTCL) is associated with selective and efficient inactivation of CXCR3-dependent T cell migration. Our studies demonstrate that this alteration is at least in part due to CXCR3 down-regulation in vivo by elevated serum levels of CXCR3 ligands. The T cell population most affected by this down-regulatory mechanism are CD8+ cytotoxic effector T cells. In CTCL patients, cytotoxic effector T cells have strongly reduced surface CXCR3 expression, accumulate in peripheral blood, but are virtually absent from CTCL tumor lesions, indicating an inability to extravasate into lymphoma tissue. CTCL-associated inactivation of effector cell recruitment may be a paradigmatic example of a new type of immune escape mechanisms shielding the neoplasm from a tumoricidal attack.<\/jats:p>","DOI":"10.4049\/jimmunol.179.6.4272","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:32:36Z","timestamp":1397849556000},"page":"4272-4282","source":"Crossref","is-referenced-by-count":17,"title":["Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients"],"prefix":"10.1093","volume":"179","author":[{"given":"Dorian","family":"Winter","sequence":"first","affiliation":[{"name":"Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences , Vienna ,","place":["Austria"]},{"name":"Division of Immunology, Allergy, and Infectious Diseases, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Moser","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy, and Infectious Diseases, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Kriehuber","sequence":"additional","affiliation":[{"name":"Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences , Vienna ,","place":["Austria"]},{"name":"Division of Immunology, Allergy, and Infectious Diseases, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy, and Infectious Diseases, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Knobler","sequence":"additional","affiliation":[{"name":"Division of Special and Environmental Dermatology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Trautinger","sequence":"additional","affiliation":[{"name":"Division of Special and Environmental Dermatology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Bombosi","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[{"name":"Division of Immunology, Allergy, and Infectious Diseases, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Petzelbauer","sequence":"additional","affiliation":[{"name":"Division of General Dermatology, Department of Dermatology, Medical University of Vienna , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antal","family":"Rot","sequence":"additional","affiliation":[{"name":"Novartis Institutes for Biomedical Research , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Maurer","sequence":"additional","affiliation":[{"name":"Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Sciences , Vienna ,","place":["Austria"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,9,15]]},"reference":[{"key":"2026012809305474800_R1","first-page":"404","volume-title":"J. 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