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In this study, we have revealed that IL-27 inhibits Th2 cell development as well as Th2 cytokines production from already polarized Th2 cells by down-regulation of GATA-3 and up-regulation of T-bet expression simultaneously. In vivo daily IL-27 treatment for 1 wk after Leishmania major infection protects BALB\/c mice from footpad swelling by diminishing parasite burden via reciprocal regulation of Th1 and Th2 responses. Furthermore, IL-27 stimulation causes marked reduction in the capacity of host mouse to mount a Th2 response against Strongyloides venezuelensis infection. Thus, IL-27-treated mice failed to develop intestinal mastocytosis after S. venezuelensis infection and exhibited a marked delay in parasite expulsion. Finally, intranasal administration of IL-27 inhibits OVA-induced airway hyperresponsiveness and inflammation in OVA-sensitized animals. Thus, IL-27 could provide us with a novel therapeutic way for treating Th2-associated diseases such as bronchial asthma.<\/jats:p>","DOI":"10.4049\/jimmunol.179.7.4415","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:54:06Z","timestamp":1397847246000},"page":"4415-4423","source":"Crossref","is-referenced-by-count":169,"title":["IL-27 Suppresses Th2 Cell Development and Th2 Cytokines Production from Polarized Th2 Cells: A Novel Therapeutic Way for Th2-Mediated Allergic Inflammation"],"prefix":"10.1093","volume":"179","author":[{"given":"Tomohiro","family":"Yoshimoto","sequence":"first","affiliation":[{"name":"Department of Immunology and Medical Zoology, Hyogo College of Medicine , Hyogo ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yoshimoto","sequence":"additional","affiliation":[{"name":"Intractable Immune System Disease Research Center, Tokyo Medical University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koubun","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology, Hyogo College of Medicine , Hyogo ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Mizuguchi","sequence":"additional","affiliation":[{"name":"Intractable Immune System Disease Research Center, Tokyo Medical University , Tokyo ,","place":["Japan"]},{"name":"Department of Immunology, Tokyo Medical University , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Immunology and Medical Zoology, Hyogo College of Medicine , Hyogo ,","place":["Japan"]},{"name":"Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"2026012810581257200_R1","first-page":"933","volume-title":"Nat. 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