{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:30:45Z","timestamp":1775251845825,"version":"3.50.1"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Regulation of CD8 T cell expansion and contraction is essential for successful immune defense against intracellular pathogens. IL-10 is a regulatory cytokine that can restrict T cell responses by inhibiting APC functions. IL-10, however, can also have direct effects on T cells. Although blockade or genetic deletion of IL-10 enhances T cell-mediated resistance to infections, the extent to which IL-10 limits in vivo APC function or T cell activation\/proliferation remains unknown. Herein, we demonstrate that primary and memory CD8 T cell responses following Listeria monocytogenes infection are enhanced by the absence of IL-10. Surface expression of the IL-10R is transiently up-regulated on CD8 T cells following activation, suggesting that activated T cells can respond to IL-10 directly. Consistent with this notion, CD8 T cells lacking IL-10R2 underwent greater expansion than wild-type T cells upon L. monocytogenes infection. The absence of IL-10R2 on APCs, in contrast, did not enhance T cell responses following infection. Our studies demonstrate that IL-10 produced during bacterial infection directly limits expansion of pathogen-specific CD8 T cells and reveal an extrinsic regulatory mechanism that modulates the magnitude of memory T cell responses.<\/jats:p>","DOI":"10.4049\/jimmunol.179.7.4520","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:54:06Z","timestamp":1397847246000},"page":"4520-4528","source":"Crossref","is-referenced-by-count":39,"title":["Pathogen-Specific CD8 T Cell Responses Are Directly Inhibited by IL-10"],"prefix":"10.1093","volume":"179","author":[{"given":"Partha Sarathi","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Medicine, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Pedicord","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ploss","sequence":"additional","affiliation":[{"name":"Center for the Study of Hepatitis C, Laboratory of Virology and Infectious Diseases, The Rockefeller University , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Menet","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid","family":"Leiner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric G","family":"Pamer","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Disease Service, Memorial Sloan-Kettering Cancer Center , New York, NY 10021"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"2026012810580689700_R1","first-page":"683","volume-title":"Annu. 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