{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:27:32Z","timestamp":1791354452728,"version":"4.3.1"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aside from being the precursors of the Ab-secreting cells, B cells are engaged in other immune functions such as Ag presentation to T cells or cytokine production. These functions may contribute to the pathogenic role of B cells in a wide range of autoimmune diseases. We demonstrate that B cells acquire the capacity to amplify IFN-\u03b3 production by CD4 and CD8 T cells during the course of the Th1 inflammatory response to Toxoplasma gondii infection. Using the two following different strategies, we observed that B cells from T. gondii-infected mice, but not from naive mice, induce higher IFN-\u03b3 expression by splenic host T cells: 1) reconstitution of B cell-deficient mice with B cells expressing an alloantigen different from the recipients, and 2) adoptive transfer of B and T cells into RAG\u2212\/\u2212 mice. In vitro assays allowing the physical separation of T and B cells demonstrate that Ag-primed B cells enhance IFN-\u03b3 production by T cells in a contact-dependent fashion. Using an OVA-transgenic strain of T. gondii and OVA-specific CD4 T cells, we observed that the proinflammatory effect of B cells is neither Ag specific nor requires MHCII expression. However, TNF-\u03b1 expressed on the surface of B cells appears to mediate in part the up-regulation of IFN-\u03b3 by the effector T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.179.7.4857","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:54:06Z","timestamp":1397847246000},"page":"4857-4866","source":"Crossref","is-referenced-by-count":100,"title":["B Cells Amplify IFN-\u03b3 Production By T Cells via a TNF-\u03b1-Mediated Mechanism"],"prefix":"10.1093","volume":"179","author":[{"given":"Laurence C","family":"Menard","sequence":"first","affiliation":[{"name":"Departments of Microbiology and Immunology, Dartmouth Medical School , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie A","family":"Minns","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology, Dartmouth Medical School , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Darche","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Re\u0301ponse Pre\u0301coce aux Parasites et Immunopathologie, Institut Pasteur-Institut National de la Recherche Agronomique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W","family":"Mielcarz","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology, Dartmouth Medical School , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Foureau","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology, Dartmouth Medical School , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roos","sequence":"additional","affiliation":[{"name":"Lynch Laboratories, Department of Biology, University of Pennsylvania , Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Dzierszinski","sequence":"additional","affiliation":[{"name":"McGill University, Institute of Parasitology , Quebec ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd H","family":"Kasper","sequence":"additional","affiliation":[{"name":"Departments of Microbiology and Immunology, Dartmouth Medical School , Lebanon, NH 03756"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Buzoni-Gatel","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Re\u0301ponse Pre\u0301coce aux Parasites et Immunopathologie, Institut Pasteur-Institut National de la Recherche Agronomique , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"2026012810581821200_R1","first-page":"253","volume-title":"Annu. 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