{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:53:29Z","timestamp":1777366409455,"version":"3.51.4"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The production of a mature B cell requires passage through a number of developmental checkpoints. The pre-BCR plays a critical role in passage through the pro-B cell\/pre-B cell checkpoint, and thus plays a central role in regulating the differentiation of a B cell. Due to the significance of this receptor, it is imperative that pre-BCR expression and function are precisely regulated. In this study, we have investigated a system in which the regulation of the pre-BCR is altered. We have found that continued expression of components of the pre-BCR (\u03bb5) resulted in a delay in the kinetics of B cell maturation. Pro-B cells from normal mouse bone marrow retrovirally infected with \u03bb5 exhibited a delay in differentiation. As compared with wild-type cells at the same time point, there is a reduction in the presence of cell surface markers that indicate developmental progression, and there is a 6- to 16-fold decrease in the production of Ig-positive cells in B cell maturation assays. The capacity to alter B cell progression by modifying and extending pre-BCR expression argues that the receptor and its associated signals play a unique role in directing developmental outcomes.<\/jats:p>","DOI":"10.4049\/jimmunol.179.8.4996","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:19:36Z","timestamp":1397848776000},"page":"4996-5005","source":"Crossref","is-referenced-by-count":9,"title":["Maintenance of Surrogate Light Chain Expression Induces Developmental Delay in Early B Cell Compartment"],"prefix":"10.1093","volume":"179","author":[{"given":"Denise A","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Kinesiology and Health Science, York University , Toronto, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Immunology Division, Department of Pathology, University of Hong Kong ,","place":["Hong Kong"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia","family":"Cascalho","sequence":"additional","affiliation":[{"name":"Department of Surgery, Immunology, and Pediatrics, Mayo Clinic College of Medicine , Rochester, MN 55905"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian E","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Health Science, York University , Toronto, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2007,10,15]]},"reference":[{"key":"2026012809302549700_R1","first-page":"951","volume-title":"J. 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