{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:51:29Z","timestamp":1791229889926,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Induction of a chronic eczema is a most efficient therapy for alopecia areata (AA). We had noted a reduction in regulatory T cells during AA induction and wondered whether regulatory T cells may become recruited or expanded during repeated skin sensitization or whether additional regulatory cells account for hair regrowth. AA could not be cured by the transfer of CD4+CD25high lymph node cells from mice repeatedly treated with a contact sensitizer. This obviously is a consequence of a dominance of freshly activated cells as compared with regulatory CD4+CD25+ T cells. Instead, a population of Gr-1+CD11b+ cells was significantly increased in skin and spleen of AA mice repeatedly treated with a contact sensitizer. Gr-1+CD11b+ spleen cells mostly expressed CD31. Expression of several proinflammatory cytokines as well as of the IFN-\u03b3 receptor and the TNF receptor I were increased. Particularly in the skin, Gr-1+ cells expressed several chemokines and CCR8 at high levels. Gr-1+CD11b+ cells most potently suppressed AA effector cell proliferation in vitro and promoted partial hair regrowth in vivo. When cocultured with CD4+ or CD8+ cells from AA mice, the Gr-1+CD11b+ cells secreted high levels of NO. However, possibly due to high level Bcl-2 protein expression in AA T cells, apoptosis induction remained unaltered. Instead, \u03b6-chain expression was strongly down-regulated, which was accompanied by a decrease in ZAP70 and ERK1\/2 phosphorylation. Thus, a chronic eczema supports the expansion and activation of myeloid suppressor cells that, via \u03b6-chain down-regulation, contribute to autoreactive T cell silencing in vitro and in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.179.8.5071","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:19:36Z","timestamp":1397848776000},"page":"5071-5081","source":"Crossref","is-referenced-by-count":68,"title":["The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Autoimmune Effector Cells by a Chronic Contact Eczema"],"prefix":"10.1093","volume":"179","author":[{"given":"Rachid","family":"Marhaba","sequence":"first","affiliation":[{"name":"Department of Tumor Progression and Immune Defense, German Cancer Research Center , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Vitacolonna","sequence":"additional","affiliation":[{"name":"Department of Tumor Progression and Immune Defense, German Cancer Research Center , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Hildebrand","sequence":"additional","affiliation":[{"name":"Department of Tumor Progression and Immune Defense, German Cancer Research Center , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Baniyash","sequence":"additional","affiliation":[{"name":"Lautenberg Center for General and Tumor Immunology, The Hebrew University, Hadassah Medical School , Jerusalem ,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Freyschmidt-Paul","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Philipps University Hospital , Marburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"Zo\u0308ller","sequence":"additional","affiliation":[{"name":"Department of Tumor Progression and Immune Defense, German Cancer Research Center , Heidelberg ,","place":["Germany"]},{"name":"Department of Applied Genetics, University of Karlsruhe ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,15]]},"reference":[{"key":"2026012809310744200_R1","first-page":"1859","volume-title":"J. 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Invest.","year":"2006"},{"key":"2026012809310744200_R21","first-page":"1568","volume-title":"Blood","year":"2007"},{"key":"2026012809310744200_R22","first-page":"2691","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2026012809310744200_R23","first-page":"6713","volume-title":"Clin. Cancer Res.","year":"2005"},{"key":"2026012809310744200_R24","first-page":"1741","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2026012809310744200_R25","first-page":"11441","volume-title":"Cancer Res.","year":"2006"},{"key":"2026012809310744200_R26","first-page":"675","volume-title":"Nat. Rev. Immunol.","year":"2004"},{"key":"2026012809310744200_R27","first-page":"64","volume-title":"Autoimmun. Rev.","year":"2006"},{"key":"2026012809310744200_R28","first-page":"643","volume-title":"Vet. Pathol.","year":"2003"},{"key":"2026012809310744200_R29","first-page":"188","volume-title":"J. Investig. Dermatol. Symp. 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