{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:45:13Z","timestamp":1786358713988,"version":"build-2736575974"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Depletion of B cells in rheumatoid arthritis is therapeutically efficacious. Yet, the mechanism by which B cells participate in the inflammatory process is unclear. We previously demonstrated that Ag-specific B cells have two important functions in the development of arthritis in a murine model of rheumatoid arthritis, proteoglycan (PG)-induced arthritis (PGIA). PG-specific B cells function as autoantibody-producing cells and as APCs that activate PG-specific T cells. Moreover, the costimulatory molecule CD86 is up-regulated on PG-specific B cells in response to stimulation with PG. To address the requirement for CD80\/CD86 expression on B cells in the development of PGIA, we generated mixed bone marrow chimeras in which CD80\/CD86 is specifically deleted on B cells and not on other APC populations. Chimeras with a specific deficiency in CD80\/CD86 expression on B cells are resistant to the induction of PGIA. The concentration of PG-specific autoantibody is similar in mice sufficient or deficient for CD80\/86-expressing B cells, which indicates that resistance to PGIA is not due to the suppression of PG-specific autoantibody production. CD80\/86-deficient B cells failed to effectively activate PG-specific autoreactive T cells as indicated by the failure of T cells from PG-immunized CD80\/86-deficient B cell chimeras to transfer arthritis into SCID mice. In vitro secondary recall responses to PG are also dependent on CD80\/86-expressing B cells. These results demonstrate that a CD80\/86:CD28 costimulatory interaction between B cells and T cells is required for autoreactive T cell activation and the induction of arthritis but not for B cell autoantibody production.<\/jats:p>","DOI":"10.4049\/jimmunol.179.8.5109","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:19:36Z","timestamp":1397848776000},"page":"5109-5116","source":"Crossref","is-referenced-by-count":104,"title":["Expression of CD80\/86 on B Cells Is Essential for Autoreactive T Cell Activation and the Development of Arthritis"],"prefix":"10.1093","volume":"179","author":[{"given":"Shannon K","family":"O\u2019Neill","sequence":"first","affiliation":[{"name":"Department of Immunology\/Microbiology, Rush University, Medical Center , Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Rheumatology, Rush University, Medical Center , Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith M","family":"Hamel","sequence":"additional","affiliation":[{"name":"Department of Immunology\/Microbiology, Rush University, Medical Center , Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D","family":"Doodes","sequence":"additional","affiliation":[{"name":"Department of Immunology\/Microbiology, Rush University, Medical Center , Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Hutas","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Section of Biochemistry and Molecular Biology, Rush University, Medical Center , Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Finnegan","sequence":"additional","affiliation":[{"name":"Department of Immunology\/Microbiology, Rush University, Medical Center , Chicago, IL 60612"},{"name":"Department of Internal Medicine, Section of Rheumatology, Rush University, Medical Center , Chicago, IL 60612"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,15]]},"reference":[{"key":"2026012809211015200_R1","first-page":"205","volume-title":"Rheumatology","year":"2001"},{"key":"2026012809211015200_R2","first-page":"2572","volume-title":"N. 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