{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:29:39Z","timestamp":1791192579151,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2007,11,1]],"date-time":"2007-11-01T00:00:00Z","timestamp":1193875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Burkitt lymphoma (BL) features translocations linking c-myc to an Ig locus. Breakpoints in the H chain locus (IgH) stand either close to JH or within switch regions and always link c-myc to the 3\u2032 IgH locus control region (3\u2032 LCR). To test the hypothesis that the 3\u2032 LCR alone was sufficient to deregulate c-myc, we generated mice carrying a 3\u2032 LCR-driven c-myc transgene and specifically up-regulating c-myc in B cells. Splenic B cells from mice proliferated exaggeratedly in response to various signals had an elevated apoptosis rate but normal B220\/IgM\/IgD expression. Although all Ig levels were lowered in vivo, class switching and Ig secretion proved normal in vitro. Beginning at the age of 12 wk, transgenic mice developed clonal lymphoblastic lymphomas or diffuse anaplastic plasmacytomas with an overall incidence of 80% by 40 wk. Lymphoblastic lymphomas were B220+IgM+IgD+ with the BL \u201cstarry sky\u201d appearance. Gene expression profiles revealed broad alterations in the proliferation program and the Ras-p21 pathway. Our study demonstrates that 3\u2032 IgH enhancers alone can deregulate c-myc and initiate the development of BL-like lymphomas. The rapid and constant occurrence of lymphoma in this model makes it valuable for the understanding and the potential therapeutic manipulation of c-myc oncogenicity in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.179.9.6033","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:27:18Z","timestamp":1397849238000},"page":"6033-6042","source":"Crossref","is-referenced-by-count":66,"title":["The 3\u2032\n                    <i>IgH<\/i>\n                    Locus Control Region Is Sufficient to Deregulate a c-\n                    <i>myc<\/i>\n                    Transgene and Promote Mature B Cell Malignancies with a Predominant Burkitt-Like Phenotype"],"prefix":"10.1093","volume":"179","author":[{"given":"Ve\u0301ronique","family":"Truffinet","sequence":"first","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pinaud","sequence":"additional","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Cogne\u0301","sequence":"additional","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Petit","sequence":"additional","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]},{"name":"Service d\u2019Anatomie Pathologique, University Hospital , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Guglielmi","sequence":"additional","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Cogne\u0301","sequence":"additional","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Denizot","sequence":"additional","affiliation":[{"name":"Unite\u0301 Mixte de Recherche, Centre National de la Recherche Scientifique 6101, Universite\u0301 de Limoges , Limoges ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,11,1]]},"reference":[{"key":"2026012809292532700_R1","first-page":"764","volume-title":"Nat. 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