{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:50:50Z","timestamp":1791093050152,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The signals driving T cell activation in T cell-mediated fulminant hepatitis are not fully understood. In this study, we identify the cytokine IL-27p28\/EBI3 as a major pathogenic factor in the ConA model of T cell-mediated hepatitis. We found an up-regulation of hepatic EBI3 and p28 expression and augmented levels of IL-27 in wild-type mice after ConA administration, suggesting a potential pathogenic role of this cytokine in ConA hepatitis. Consistently, IL-27 EBI3-deficient mice were almost completely protected from ConA-induced liver damage. Such protection was associated with reduced levels of IFN-\u03b3 and its signaling proteins pSTAT-1 and T-bet. Finally, in vivo blockade of IL-27 function using a soluble IL-27 receptor fusion protein led to reduced pSTAT1 levels and suppression of liver injury. Taken together, these data demonstrate a key pathogenic role of IL-27 in T cell-mediated liver injury. Furthermore, in vivo blockade of IL-27 emerges as a novel potential therapy for T cell-mediated hepatitis.<\/jats:p>","DOI":"10.4049\/jimmunol.180.1.30","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T04:13:32Z","timestamp":1397189612000},"page":"30-33","source":"Crossref","is-referenced-by-count":37,"title":["Cutting Edge: A Key Pathogenic Role of IL-27 in T Cell- Mediated Hepatitis"],"prefix":"10.1093","volume":"180","author":[{"given":"Juergen","family":"Siebler","sequence":"first","affiliation":[{"name":"First Department of Medicine, University of Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wirtz","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University of Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Frenzel","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University of Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Schuchmann","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University of Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W","family":"Lohse","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University of Hamburg , Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Galle","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University of Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus F","family":"Neurath","sequence":"additional","affiliation":[{"name":"First Department of Medicine, University of Mainz , Mainz ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"2025032610014911100_R1","first-page":"779","volume-title":"Immunity","year":"2002"},{"key":"2025032610014911100_R2","first-page":"4886","volume-title":"J. Immunol.","year":"2003"},{"key":"2025032610014911100_R3","first-page":"513","volume-title":"J. Interferon Cytokine Res.","year":"2003"},{"key":"2025032610014911100_R4","first-page":"15047","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2003"},{"key":"2025032610014911100_R5","first-page":"569","volume-title":"Immunity","year":"2001"},{"key":"2025032610014911100_R6","first-page":"1663","volume-title":"Eur. J. Immunol.","year":"2007"},{"key":"2025032610014911100_R7","first-page":"916","volume-title":"Nature","year":"2000"},{"key":"2025032610014911100_R8","first-page":"645","volume-title":"Immunity","year":"2003"},{"key":"2025032610014911100_R9","first-page":"16951","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2025032610014911100_R10","first-page":"657","volume-title":"Immunity","year":"2003"},{"key":"2025032610014911100_R11","first-page":"1079","volume-title":"Hepatology","year":"2003"},{"key":"2025032610014911100_R12","first-page":"462","volume-title":"Gastroenterology","year":"1996"},{"key":"2025032610014911100_R13","first-page":"1573","volume-title":"Hepatology","year":"2003"},{"key":"2025032610014911100_R14","first-page":"860","volume-title":"J. Clin. Invest.","year":"2005"},{"key":"2025032610014911100_R15","first-page":"567","volume-title":"Nat. Med.","year":"2002"},{"key":"2025032610014911100_R16","first-page":"3871","volume-title":"J. Immunol.","year":"2004"},{"key":"2025032610014911100_R17","first-page":"1875","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2025032610014911100_R18","first-page":"3590","volume-title":"J. Immunol.","year":"2004"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/1\/30\/62676204\/zim00108000030.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/1\/30\/62676204\/zim00108000030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T14:16:12Z","timestamp":1743257772000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/180\/1\/30\/8022058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.180.1.30","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,1]]},"published":{"date-parts":[[2008,1,1]]}}}