{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:27:05Z","timestamp":1792106825426,"version":"4.4.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated an otherwise healthy patient presenting two episodes of staphylococcal cellulitis and abscesses, accompanied by high fever and biological signs of inflammation but, paradoxically, with no detectable increase in serum levels of C-reactive protein (CRP), an IL-6-responsive protein synthesized in the liver. Following in vitro activation of whole blood cells from the patient with multiple cytokines, TLR agonists, heat-killed bacteria, and mitogens, we observed a profound and specific impairment of IL-6 secretion. However, the patient\u2019s PBMCs, activated in the same conditions but in the absence of the patient\u2019s plasma, secreted IL-6 normally. The patient\u2019s serum contained high titers of IgG1 autoantibodies against IL-6, which specifically neutralized IL-6 production by control PBMCs as well as IL-6 responses in the human hepatocellular carcinoma cell line Hep3B. These anti-IL-6 autoantibodies were detected over a period of 4 years, in the absence of any other autoantibodies. Our results indicate that these Abs probably prevented an increase in CRP concentration during infection and that impaired IL-6-mediated immunity may have contributed to staphylococcal disease. Patients with severe bacterial infections and low serum CRP concentrations should be tested for anti-IL-6 autoantibodies, especially in the presence of other clinical and biological signs of inflammation.<\/jats:p>","DOI":"10.4049\/jimmunol.180.1.647","type":"journal-article","created":{"date-parts":[[2014,4,11]],"date-time":"2014-04-11T00:13:32Z","timestamp":1397175212000},"page":"647-654","source":"Crossref","is-referenced-by-count":175,"title":["Recurrent Staphylococcal Cellulitis and Subcutaneous Abscesses in a Child with Autoantibodies against IL-6"],"prefix":"10.1093","volume":"180","author":[{"given":"Anne","family":"Puel","sequence":"first","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Humaine des Maladies Infectieuses, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U550 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Picard","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Humaine des Maladies Infectieuses, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U550 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]},{"name":"Centre d\u2019E\u0301tude des de\u0301ficits immunitaires , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathie","family":"Lorrot","sequence":"additional","affiliation":[{"name":"Pe\u0301diatrie Ge\u0301ne\u0301rale, Groupe Hospitalier Cochin-Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Pons","sequence":"additional","affiliation":[{"name":"Pe\u0301diatrie Ge\u0301ne\u0301rale, Groupe Hospitalier Cochin-Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Chrabieh","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Humaine des Maladies Infectieuses, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U550 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazaro","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Humaine des Maladies Infectieuses, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U550 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mamani-Matsuda","sequence":"additional","affiliation":[{"name":"Laboratoire du De\u0301veloppement du Syste\u0300me Immunitaire, U783 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Jouanguy","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Humaine des Maladies Infectieuses, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U550 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Gendrel","sequence":"additional","affiliation":[{"name":"Pe\u0301diatrie Ge\u0301ne\u0301rale, Groupe Hospitalier Cochin-Saint Vincent de Paul , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Laurent","family":"Casanova","sequence":"additional","affiliation":[{"name":"Laboratoire de Ge\u0301ne\u0301tique Humaine des Maladies Infectieuses, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, U550 , Paris ,","place":["France"]},{"name":"Universite\u0301 Paris Rene\u0301 Descartes , Paris ,","place":["France"]},{"name":"Unite\u0301 d\u2019He\u0301matologie et d\u2019Immunologie Pe\u0301diatriques, Ho\u0302pital Necker-Enfants Malades , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,1,1]]},"reference":[{"key":"2025032610000448100_R1","first-page":"578","volume-title":"Curr. Opin. Immunol.","year":"2003"},{"key":"2025032610000448100_R2","first-page":"244","volume-title":"Immunol. Rev.","year":"2005"},{"key":"2025032610000448100_R3","first-page":"34","volume-title":"Curr. Opin. Immunol.","year":"2004"},{"key":"2025032610000448100_R4","first-page":"10","volume-title":"Immunol. Rev.","year":"2005"},{"key":"2025032610000448100_R5","first-page":"1058","volume-title":"Nature","year":"2007"},{"key":"2025032610000448100_R6","first-page":"1608","volume-title":"N. Engl. J. Med.","year":"2007"},{"key":"2025032610000448100_R7","first-page":"3195","volume-title":"Nucleic Acids Res.","year":"1988"},{"key":"2025032610000448100_R8","first-page":"347","volume-title":"FEBS Lett.","year":"1988"},{"key":"2025032610000448100_R9","first-page":"237","volume-title":"FEBS Lett.","year":"1989"},{"key":"2025032610000448100_R10","first-page":"3773","volume-title":"EMBO J.","year":"1989"},{"key":"2025032610000448100_R11","first-page":"621","volume-title":"Biochem. J.","year":"1990"},{"key":"2025032610000448100_R12","first-page":"4136","volume-title":"J. Biol. Chem.","year":"1990"},{"key":"2025032610000448100_R13","first-page":"457","volume-title":"EMBO J.","year":"1990"},{"key":"2025032610000448100_R14","first-page":"9503","volume-title":"J. Biol. Chem.","year":"1996"},{"key":"2025032610000448100_R15","first-page":"2378","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032610000448100_R16","first-page":"3386","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032610000448100_R17","first-page":"189","volume-title":"Mol. Immunol.","year":"2001"},{"key":"2025032610000448100_R18","first-page":"399","volume-title":"Nat. Genet.","year":"1997"},{"key":"2025032610000448100_R19","first-page":"393","volume-title":"Nat. Genet.","year":"1997"},{"key":"2025032610000448100_R20","first-page":"1395","volume-title":"Science","year":"2002"},{"key":"2025032610000448100_R21","first-page":"e289","volume-title":"PLoS Med.","year":"2006"},{"key":"2025032610000448100_R22","first-page":"617","volume-title":"Science","year":"2007"},{"key":"2025032610000448100_R23","first-page":"619","volume-title":"Nat. Clin. Pract. Rheumatol.","year":"2006"},{"key":"2025032610000448100_R24","first-page":"339","volume-title":"Nature","year":"1994"},{"key":"2025032610000448100_R25","first-page":"439","volume-title":"J. Infect. Dis.","year":"1997"},{"key":"2025032610000448100_R26","first-page":"3745","volume-title":"Infect. Immun.","year":"2005"},{"key":"2025032610000448100_R27","first-page":"581","volume-title":"Eur. Cytokine Network","year":"2001"},{"key":"2025032610000448100_R28","first-page":"165","volume-title":"Int. Arch. Allergy Immunol.","year":"2003"},{"key":"2025032610000448100_R29","first-page":"3231","volume-title":"Infect. Immun.","year":"1996"},{"key":"2025032610000448100_R30","first-page":"360","volume-title":"J. Infect. Dis.","year":"2006"},{"key":"2025032610000448100_R31","first-page":"651","volume-title":"Immunobiology","year":"2005"},{"key":"2025032610000448100_R32","first-page":"745","volume-title":"Immunity","year":"2006"},{"key":"2025032610000448100_R33","first-page":"283","volume-title":"Biochem. J.","year":"1990"},{"key":"2025032610000448100_R34","first-page":"1703","volume-title":"J. Exp. Med.","year":"1981"},{"key":"2025032610000448100_R35","first-page":"2374","volume-title":"J. Immunol.","year":"1982"},{"key":"2025032610000448100_R36","first-page":"2557","volume-title":"J. Immunol.","year":"1995"},{"key":"2025032610000448100_R37","first-page":"631","volume-title":"J. Exp. Med.","year":"1998"},{"key":"2025032610000448100_R38","first-page":"437","volume-title":"Mol. Microbiol.","year":"2002"},{"key":"2025032610000448100_R39","first-page":"141","volume-title":"Mycoses","year":"1991"},{"key":"2025032610000448100_R40","first-page":"341","volume-title":"FEMS Microbiol. Immunol.","year":"1991"},{"key":"2025032610000448100_R41","first-page":"941","volume-title":"Clin. Exp. Immunol.","year":"1971"},{"key":"2025032610000448100_R42","first-page":"392","volume-title":"Infect. Immun.","year":"1982"},{"key":"2025032610000448100_R43","first-page":"5652","volume-title":"Infect. Immun.","year":"2000"},{"key":"2025032610000448100_R44","first-page":"1158","volume-title":"J. Immunol.","year":"2007"},{"key":"2025032610000448100_R45","first-page":"62","volume-title":"Int. J. Tuberc. Lung Dis.","year":"1998"},{"key":"2025032610000448100_R46","first-page":"e10","volume-title":"Clin. Infect. Dis.","year":"2004"},{"key":"2025032610000448100_R47","first-page":"673","volume-title":"Blood","year":"2004"},{"key":"2025032610000448100_R48","first-page":"4769","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032610000448100_R49","first-page":"2480","volume-title":"J. Clin. Invest.","year":"2005"},{"key":"2025032610000448100_R50","first-page":"167","volume-title":"Immunol. Today","year":"1990"},{"key":"2025032610000448100_R51","first-page":"57","volume-title":"Clin. Exp. Immunol.","year":"1990"},{"key":"2025032610000448100_R52","first-page":"695","volume-title":"Scand. J. Immunol.","year":"1990"},{"key":"2025032610000448100_R53","first-page":"133","volume-title":"Immunol. Lett.","year":"1991"},{"key":"2025032610000448100_R54","first-page":"407","volume-title":"Clin. Exp. Immunol.","year":"1991"},{"key":"2025032610000448100_R55","first-page":"80","volume-title":"Clin. Exp. Immunol.","year":"1991"},{"key":"2025032610000448100_R56","first-page":"330","volume-title":"Clin. Exp. Immunol.","year":"1992"},{"key":"2025032610000448100_R57","first-page":"125","volume-title":"Cytokine","year":"1992"},{"key":"2025032610000448100_R58","first-page":"472","volume-title":"Scand. J. Immunol.","year":"1993"},{"key":"2025032610000448100_R59","first-page":"107","volume-title":"Immunopharmacology","year":"1994"},{"key":"2025032610000448100_R60","first-page":"212","volume-title":"Eur. J. Clin. Invest.","year":"1994"},{"key":"2025032610000448100_R61","first-page":"649","volume-title":"Mol. Immunol.","year":"1996"},{"key":"2025032610000448100_R62","first-page":"164","volume-title":"Scand. J. Rheumatol.","year":"1996"},{"key":"2025032610000448100_R63","first-page":"283","volume-title":"J. Clin. Immunol.","year":"1996"},{"key":"2025032610000448100_R64","first-page":"173","volume-title":"Clin. Exp. Immunol.","year":"1996"},{"key":"2025032610000448100_R65","first-page":"2155","volume-title":"Eur. J. Immunol.","year":"1996"},{"key":"2025032610000448100_R66","first-page":"S35","volume-title":"J. Interferon Cytokine Res.","year":"1997"},{"key":"2025032610000448100_R67","first-page":"2376","volume-title":"Blood","year":"1997"},{"key":"2025032610000448100_R68","first-page":"209","volume-title":"Immunol. Today","year":"1998"},{"key":"2025032610000448100_R69","first-page":"63","volume-title":"J. Dermatol. Sci.","year":"1998"},{"key":"2025032610000448100_R70","first-page":"2054","volume-title":"Blood","year":"1998"},{"key":"2025032610000448100_R71","first-page":"526","volume-title":"Immunology","year":"1999"},{"key":"2025032610000448100_R72","first-page":"207","volume-title":"J. Interferon Cytokine Res.","year":"2002"},{"key":"2025032610000448100_R73","first-page":"102","volume-title":"J. Neuroimmunol.","year":"2003"},{"key":"2025032610000448100_R74","first-page":"903","volume-title":"Int. Immunol.","year":"2003"},{"key":"2025032610000448100_R75","first-page":"777","volume-title":"Scand. J. Immunol.","year":"1991"},{"key":"2025032610000448100_R76","first-page":"72","volume-title":"Cytokine","year":"1993"},{"key":"2025032610000448100_R77","first-page":"2533","volume-title":"J. Clin. Invest.","year":"1993"},{"key":"2025032610000448100_R78","first-page":"1113","volume-title":"Leukemia","year":"1995"},{"key":"2025032610000448100_R79","first-page":"1145","volume-title":"Blood","year":"1995"},{"key":"2025032610000448100_R80","first-page":"348","volume-title":"Eur. J. Immunol.","year":"1995"},{"key":"2025032610000448100_R81","first-page":"3267","volume-title":"Eur. J. Immunol.","year":"2004"},{"key":"2025032610000448100_R82","first-page":"197","volume-title":"Scand. J. Rheumatol.","year":"1995"},{"key":"2025032610000448100_R83","first-page":"935","volume-title":"J. Immunol.","year":"1994"},{"key":"2025032610000448100_R84","first-page":"940","volume-title":"Arthritis Rheum.","year":"1992"},{"key":"2025032610000448100_R85","first-page":"623","volume-title":"Scand. J. Immunol.","year":"1996"},{"key":"2025032610000448100_R86","first-page":"2407","volume-title":"J. Exp. Med.","year":"2007"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/1\/647\/62672891\/zim00108000647.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/1\/647\/62672891\/zim00108000647.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T09:58:44Z","timestamp":1743242324000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/180\/1\/647\/8021767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1,1]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.180.1.647","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,1]]},"published":{"date-parts":[[2008,1,1]]}}}