{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:45:54Z","timestamp":1773240354450,"version":"3.50.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hereditary properdin deficiency is linked to susceptibility to meningococcal disease (Neisseria meningitidis serotypes Y and W-135) with high mortality. Its relative contribution toward the outcome of nonseptic shock has not been investigated. Using properdin-deficient C57BL\/6 mice and their littermates, this study examines their survival of zymosan-induced and LPS-induced shock. Properdin-deficient mice were more resistant to zymosan shock compared with wild-type mice, which showed greater impairment of end-organ function 24 h after zymosan injection, higher TNF-\u03b1 production by alveolar and peritoneal macrophages, higher TNF-\u03b1, and, inversely, lower IL-10 levels in peritoneal lavage and circulation and higher plasma C5a levels. Properdin-deficient mice showed significantly higher mortality in LPS shock, elevated TNF-\u03b1, and, inversely, reduced IL-10 production by peritoneal macrophages as well as lower plasma C5a levels compared with wild-type littermates. NO production by peritoneal macrophages and plasma \u03b11-antitrypsin levels at 24 h after the injection of LPS or zymosan were decreased in properdin-deficient mice in both models, and fewer histopathologic changes in liver were observed in properdin-deficient animals. This study provides evidence that properdin deficiency attenuates zymosan-induced shock and exacerbates LPS-induced shock.<\/jats:p>","DOI":"10.4049\/jimmunol.180.10.6962","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:52:44Z","timestamp":1397847164000},"page":"6962-6969","source":"Crossref","is-referenced-by-count":23,"title":["Properdin Deficiency in Murine Models of Nonseptic Shock"],"prefix":"10.1093","volume":"180","author":[{"given":"Nina D","family":"Ivanovska","sequence":"first","affiliation":[{"name":"Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences , Sofia ,","place":["Bulgaria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petya A","family":"Dimitrova","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences , Sofia ,","place":["Bulgaria"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeni C","family":"Luckett","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Inflammation, University of Leicester , Leicester ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"El-Rachkidy Lonnen","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Inflammation, University of Leicester , Leicester ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm J","family":"Schwaeble","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Inflammation, University of Leicester , Leicester ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cordula M","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Infection, Immunity and Inflammation, University of Leicester , Leicester ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,5,15]]},"reference":[{"key":"2026012809153495500_R1","first-page":"1631","volume-title":"Mol. 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