{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:06:00Z","timestamp":1784037960245,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tissue trauma in the peritoneal and pelvic cavities following surgery or bacterial infection results in adhesions that are a debilitating cause of intestinal obstruction, chronic pelvic pain, and infertility in women. We recently demonstrated that CD4+ \u03b1\u03b2 T cells are essential for development of this process. Using a murine model of experimental adhesion formation, we now demonstrate that adhesion formation is characterized by the selective recruitment of Tim-3+, CCR5+, CXCR3+, IFN-\u03b3+ cells, indicating the presence of a Th1 phenotype. We further demonstrate that adhesion formation is critically dependent on the function of Th1 cells because mice genetically deficient for IFN-\u03b3, T-bet, or treated with Abs to the Th1-selective chemoattractant IL-16 show significantly less adhesion formation than wild-type mice. In addition, disrupting the interaction of the Th1-specific regulatory molecule Tim-3, with its ligand, significantly exacerbates adhesion formation. This enhanced response is associated with increases in the level of neutrophil-attracting chemokines KC and MIP-2, known to play a role in adhesiogenesis. These data demonstrate that the CD4+ T cells orchestrating adhesion formation are of the Th1 phenotype and delineate the central role of T-bet, Tim-3, IFN-\u03b3, and IL-16 in mediating this pathogenic tissue response.<\/jats:p>","DOI":"10.4049\/jimmunol.180.10.6970","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:52:44Z","timestamp":1397847164000},"page":"6970-6976","source":"Crossref","is-referenced-by-count":28,"title":["Functional Th1 Cells Are Required for Surgical Adhesion Formation in a Murine Model"],"prefix":"10.1093","volume":"180","author":[{"given":"Arthur O","family":"Tzianabos","sequence":"first","affiliation":[{"name":"Department of Medicine and Channing Laboratory, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A","family":"Holsti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Channing Laboratory, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Xiao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur F","family":"Stucchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Boston University Medical Center, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay K","family":"Kuchroo","sequence":"additional","affiliation":[{"name":"Center for Neurologic Diseases, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry B","family":"Strom","sequence":"additional","affiliation":[{"name":"Division of Immunology, Beth Israel Deaconess Medical Center and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H","family":"Glimcher","sequence":"additional","affiliation":[{"name":"Harvard School of Public Health and Harvard Medical School , Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W","family":"Cruikshank","sequence":"additional","affiliation":[{"name":"Pulmonary Center, Boston University School of Medicine , Boston, MA 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,5,15]]},"reference":[{"key":"2026012809170667600_R1","first-page":"395","volume-title":"Fertil. 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