{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T07:01:33Z","timestamp":1789628493673,"version":"build-2803163510"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To identify basic mechanisms of how infections may induce a neuron-specific autoimmune response, we generated mice expressing OVA as neuronal autoantigen under control of the neuron-specific enolase promoter (NSE-OVA mice). Intracerebral, but not systemic, infection with attenuated Listeria monocytogenes-secreting OVA induced an atactic-paretic neurological syndrome in NSE-OVA mice after bacterial clearance from the brain, whereas wild-type mice remained healthy. Immunization with attenuated Listeria monocytogenes-secreting OVA before intracerebral infection strongly increased the number of intracerebral OVA-specific CD8 T cells aggravating neurological disease. T cell depletion and adoptive transfer experiments identified CD8 T cells as decisive mediators of the autoimmune disease. Importantly, NSE-OVA mice having received OVA-specific TCR transgenic CD8 T cells developed an accelerated, more severe, and extended neurological disease. Adoptively transferred pathogenic CD8 T cells specifically homed to OVA-expressing MHC class I+ neurons and, corresponding to the clinical symptoms, \u223c30% of neurons in the anterior horn of the spinal cord became apoptotic. Thus, molecular mimicry between a pathogen and neurons can induce a CD8 T cell-mediated neurological disease, with its severity being influenced by the frequency of specific CD8 T cells, and its induction, but not its symptomatic phase, requiring the intracerebral presence of the pathogen.<\/jats:p>","DOI":"10.4049\/jimmunol.180.12.8421","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:24:59Z","timestamp":1397849099000},"page":"8421-8433","source":"Crossref","is-referenced-by-count":23,"title":["Molecular Mimicry between Neurons and an Intracerebral Pathogen Induces a CD8 T Cell-Mediated Autoimmune Disease"],"prefix":"10.1093","volume":"180","author":[{"given":"Monica","family":"Sanchez-Ruiz","sequence":"first","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Universita\u0308tsklinikum Ko\u0308ln , Ko\u0308ln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Wilden","sequence":"additional","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Universita\u0308tsklinikum Ko\u0308ln , Ko\u0308ln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Mu\u0308ller","sequence":"additional","affiliation":[{"name":"Helmholtz Zentrum fu\u0308r Infektionsforschung, Experimentelle Immunologie , Braunschweig"},{"name":"University of Manchester , Manchester ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Stenzel","sequence":"additional","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Universita\u0308tsklinikum Ko\u0308ln , Ko\u0308ln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Brunn","sequence":"additional","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Universita\u0308tsklinikum Ko\u0308ln , Ko\u0308ln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hrvoje","family":"Miletic","sequence":"additional","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Universita\u0308tsklinikum Ko\u0308ln , Ko\u0308ln"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Schlu\u0308ter","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Deckert","sequence":"additional","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Universita\u0308tsklinikum Ko\u0308ln , Ko\u0308ln"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,6,15]]},"reference":[{"key":"2025032701445052700_R1","first-page":"80","volume-title":"Clin. 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