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Ag-stimulated CTLs serially engage autologous B lymphocytes through CD27\/CD70 contact that promotes their survival and proliferation. Moreover, these interactions induce the release of proinflammatory cytokines that follows two general patterns: 1) an epitope-dependent enhancement of cytokine release, and 2) a previously undiscovered coordinate release of cytokines independent of epitope exposure. The latter includes chemoattractants targeting activated T cells. As a result, activated T cells are attracted to B cells, which exert a \u201chelper\u201d role in lymphatic organs or in areas of inflammation. This observation provides a mechanistic explanation to previously reported experimental observations suggesting that B cells are required for T cell priming in vivo.<\/jats:p>","DOI":"10.4049\/jimmunol.180.3.1362","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:54:53Z","timestamp":1397861693000},"page":"1362-1372","source":"Crossref","is-referenced-by-count":85,"title":["Helper B Cells Promote Cytotoxic T Cell Survival and Proliferation Independently of Antigen Presentation through CD27\/CD70 Interactions"],"prefix":"10.1093","volume":"180","author":[{"given":"Sara","family":"Deola","sequence":"first","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica C","family":"Panelli","sequence":"additional","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Maric","sequence":"additional","affiliation":[{"name":"Flow Cytometry Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Selleri","sequence":"additional","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"},{"name":"Department of Human Morphology, Universita\u0301 degli Studi di Milano , Milan ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia I","family":"Dmitrieva","sequence":"additional","affiliation":[{"name":"Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching Y","family":"Voss","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Center, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Klein","sequence":"additional","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Stroncek","sequence":"additional","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ena","family":"Wang","sequence":"additional","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco M","family":"Marincola","sequence":"additional","affiliation":[{"name":"Infectious Disease and Immunogenetics Section, Department of Transfusion Medicine, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"2025032610022094900_R1","first-page":"4260","volume-title":"Blood","year":"2003"},{"key":"2025032610022094900_R2","first-page":"921","volume-title":"Science","year":"1990"},{"key":"2025032610022094900_R3","first-page":"1439","volume-title":"J. 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