{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:35:02Z","timestamp":1778693702373,"version":"3.51.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>PGE2 inhibits mature T cell proliferation and protects T cells from activation-induced cell death (AICD). We have previously demonstrated that human follicular dendritic cells (FDC) strongly express PGI synthase. In this study, the hypothesis that FDC have regulatory roles on germinal center T cells by controlling production of PGE2 and PGI2 was tested. Confocal microscopic analyses of human tonsil tissues revealed that FDC indeed expressed PGE synthase in addition to PGIS. To confirm these results, we studied the regulation mechanism of PG production in FDC, using an established human FDC-like cell line, HK. Specifically in response to TNF-\u03b1, TGF-\u03b2, and LPS, protein expression of cyclooxygenase (COX)-2 and downstream PGE synthase was up-regulated with coordinate kinetics, whereas COX-1 and PGIS were constitutively expressed. The increase of these enzymes was reflected in actual production of PGE2 and PGI2. Interestingly, IL-4 almost completely abrogated the stimulatory activity of TNF-\u03b1, TGF-\u03b2, and LPS in PG production. Furthermore, the up-regulation of PGE2 and PGI2 production was markedly down-regulated by indomethacin and a selective COX-2 inhibitor. PGI2 analog and PGE2 inhibited proliferation and AICD of T cells in dose- and time-dependent manners. Finally, coculture experiments revealed that HK cells indeed inhibit proliferation and AICD of T cells. Put together, these results show an unrecognized pathway of FDC and T cell interactions and differential mechanisms for PGE2 and PGI2 production, suggesting an important implication for development and use of anti-inflammatory drugs.<\/jats:p>","DOI":"10.4049\/jimmunol.180.3.1390","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T22:54:53Z","timestamp":1397861693000},"page":"1390-1397","source":"Crossref","is-referenced-by-count":28,"title":["Human Follicular Dendritic Cells Interact with T Cells via Expression and Regulation of Cyclooxygenases and Prostaglandin E and I Synthases"],"prefix":"10.1093","volume":"180","author":[{"given":"In Yong","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine, Kangwon National University , Chunchon ,","place":["Korea"]},{"name":"Vascular System Research Center, Kangwon National University , Chunchon ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whajung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine, Kangwon National University , Chunchon ,","place":["Korea"]},{"name":"Vascular System Research Center, Kangwon National University , Chunchon ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jini","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine, Kangwon National University , Chunchon ,","place":["Korea"]},{"name":"Vascular System Research Center, Kangwon National University , Chunchon ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan-Sik","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jongseon","family":"Choe","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, College of Medicine, Kangwon National University , Chunchon ,","place":["Korea"]},{"name":"Vascular System Research Center, Kangwon National University , Chunchon ,","place":["Korea"]},{"name":"Research Institute of Life Sciences, Kangwon National University , Chunchon ,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,2,1]]},"reference":[{"key":"2025032610021816900_R1","first-page":"201","volume-title":"Immunol. 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