{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:05:33Z","timestamp":1791320733267,"version":"4.3.1"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Influenza A virus (IAV) triggers a contagious respiratory disease that produces considerable lethality. Although this lethality is likely due to an excessive host inflammatory response, the negative feedback mechanisms aimed at regulating such a response are unknown. In this study, we investigated the role of the eight \u201csuppressor of cytokine signaling\u201d (SOCS) regulatory proteins in IAV-triggered cytokine expression in human respiratory epithelial cells. SOCS1 to SOCS7, but not cytokine-inducible Src homology 2-containing protein (CIS), are constitutively expressed in these cells and only SOCS1 and SOCS3 expressions are up-regulated upon IAV challenge. Using distinct approaches affecting the expression and\/or the function of the IFN\u03b1\u03b2 receptor (IFNAR)1, the viral sensors TLR3 and retinoic acid-inducible gene I (RIG-I) as well as the mitochondrial antiviral signaling protein (MAVS, a RIG-I signaling intermediate), we demonstrated that SOCS1 and SOCS3 up-regulation requires a TLR3-independent, RIG-I\/MAVS\/IFNAR1-dependent pathway. Importantly, by using vectors overexpressing SOCS1 and SOCS3 we revealed that while both molecules inhibit antiviral responses, they differentially modulate inflammatory signaling pathways.<\/jats:p>","DOI":"10.4049\/jimmunol.180.4.2034","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:26:28Z","timestamp":1397863588000},"page":"2034-2038","source":"Crossref","is-referenced-by-count":137,"title":["Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I\/IFNAR1-Dependent Pathway"],"prefix":"10.1093","volume":"180","author":[{"given":"Julien","family":"Pothlichet","sequence":"first","affiliation":[{"name":"Institut Pasteur, Unite\u0301 De\u0301fense Inne\u0301e et Inflammation , Paris ,","place":["France"]},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 874 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Chignard","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 De\u0301fense Inne\u0301e et Inflammation , Paris ,","place":["France"]},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 874 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Si-Tahar","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Unite\u0301 De\u0301fense Inne\u0301e et Inflammation , Paris ,","place":["France"]},{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 874 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,2,15]]},"reference":[{"key":"2025032700594030900_R1","first-page":"2285","volume-title":"J. Gen. Virol.","year":"2003"},{"key":"2025032700594030900_R2","first-page":"S82","volume-title":"Nat. Med.","year":"2204"},{"key":"2025032700594030900_R3","first-page":"723","volume-title":"Clin. Infect. Dis.","year":"2007"},{"key":"2025032700594030900_R4","first-page":"135","volume-title":"Respir. Res.","year":"2005"},{"key":"2025032700594030900_R5","first-page":"1203","volume-title":"Nat. Med.","year":"2006"},{"key":"2025032700594030900_R6","first-page":"243","volume-title":"Clin. Microbiol. Rev.","year":"2007"},{"key":"2025032700594030900_R7","first-page":"319","volume-title":"Nature","year":"2007"},{"key":"2025032700594030900_R8","first-page":"5","volume-title":"J. Leukocyte Biol.","year":"2004"},{"key":"2025032700594030900_R9","first-page":"236","volume-title":"Jpn. J. Infect. Dis.","year":"2004"},{"key":"2025032700594030900_R10","first-page":"997","volume-title":"Science","year":"2006"},{"key":"2025032700594030900_R11","first-page":"994","volume-title":"Science","year":"2006"},{"key":"2025032700594030900_R12","first-page":"3368","volume-title":"J. Immunol.","year":"2007"},{"key":"2025032700594030900_R13","first-page":"5571","volume-title":"J. Biol. Chem.","year":"2005"},{"key":"2025032700594030900_R14","first-page":"e53","volume-title":"PLoS Pathog.","year":"2006"},{"key":"2025032700594030900_R15","first-page":"109","volume-title":"Vet. Microbiol.","year":"2000"},{"key":"2025032700594030900_R16","first-page":"171","volume-title":"Cytokine Growth Factor Rev.","year":"2001"},{"key":"2025032700594030900_R17","first-page":"503","volume-title":"Annu. Rev. Immunol.","year":"2004"},{"key":"2025032700594030900_R18","first-page":"454","volume-title":"Nat. Rev. Immunol.","year":"2007"},{"key":"2025032700594030900_R19","first-page":"2712","volume-title":"J. Biol. Chem.","year":"2004"},{"key":"2025032700594030900_R20","first-page":"641","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2025032700594030900_R21","first-page":"6282","volume-title":"J. Virol.","year":"2004"},{"key":"2025032700594030900_R22","first-page":"302","volume-title":"Nat. Immunol.","year":"2006"},{"key":"2025032700594030900_R23","first-page":"373","volume-title":"Immunity","year":"2006"},{"key":"2025032700594030900_R24","first-page":"101","volume-title":"Nature","year":"2006"},{"key":"2025032700594030900_R25","first-page":"1401","volume-title":"J. Virol.","year":"2007"},{"key":"2025032700594030900_R26","first-page":"582","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2007"},{"key":"2025032700594030900_R27","first-page":"33","volume-title":"Nat. Immunol.","year":"2006"},{"key":"2025032700594030900_R28","first-page":"1574","volume-title":"J. Invest. Dermatol.","year":"2006"},{"key":"2025032700594030900_R29","first-page":"349","volume-title":"Immunity.","year":"2006"},{"key":"2025032700594030900_R30","first-page":"148","volume-title":"Nat. Immunol.","year":"2006"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/4\/2034\/62672700\/zim00408002034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/4\/2034\/62672700\/zim00408002034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T23:18:10Z","timestamp":1743290290000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/180\/4\/2034\/8055973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,2,15]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.180.4.2034","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,2]]},"published":{"date-parts":[[2008,2]]}}}