{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:52:07Z","timestamp":1791046327261,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Expression of IL-7R\u03b1 (CD127) has been suggested as a major determinant in the survival of memory T cell precursors. We investigated whether constitutive expression of IL-7R\u03b1 on T cells increased expansion and\/or decreased contraction of endogenous Ag-specific CD4 and CD8 T cells following infection with Listeria monocytogenes. The results indicate that constitutive expression of IL-7R\u03b1 alone was not enough to impart an expansion or survival advantage to CD8 T cells responding to infection, and did not increase memory CD8 T cell numbers over those observed in wild-type controls. Constitutive expression of IL-7R\u03b1 did allow for slightly prolonged expansion of Ag-specific CD4 T cells; however, it did not alter the contraction phase or protect against the waning of memory T cell numbers at later times after infection. Memory CD4 and CD8 T cells generated in IL-7R\u03b1 transgenic mice expanded similarly to wild-type T cells after secondary infection, and immunized IL-7R\u03b1 transgenic mice were fully protected against lethal bacterial challenge demonstrating that constitutive expression of IL-7R\u03b1 does not impair, or markedly improve memory\/secondary effector T cell function. These results indicate that expression of IL-7R\u03b1 alone does not support increased survival of effector Ag-specific CD4 or CD8 T cells into the memory phase following bacterial infection.<\/jats:p>","DOI":"10.4049\/jimmunol.180.5.2855","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:16:52Z","timestamp":1397863012000},"page":"2855-2862","source":"Crossref","is-referenced-by-count":52,"title":["Constitutive Expression of IL-7 Receptor \u03b1 Does Not Support Increased Expansion or Prevent Contraction of Antigen-Specific CD4 or CD8 T Cells following <i>Listeria monocytogenes<\/i> Infection"],"prefix":"10.1093","volume":"180","author":[{"given":"Jodie S","family":"Haring","sequence":"first","affiliation":[{"name":"Department of Microbiology, Carver School of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefang","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Carver School of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Bollenbacher-Reilley","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Hui","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Carver School of Medicine, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J","family":"Leonard","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20824"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John T","family":"Harty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Carver School of Medicine, University of Iowa , Iowa City, IA 52242"},{"name":"Interdisciplinary Graduate Program in Immunology, University of Iowa , Iowa City, IA 52242"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"2025032701004513300_R1","first-page":"67","volume-title":"Immunol. Rev.","year":"2006"},{"key":"2025032701004513300_R2","first-page":"6571","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032701004513300_R3","first-page":"1515","volume-title":"J. Exp. Med.","year":"2002"},{"key":"2025032701004513300_R4","first-page":"426","volume-title":"Nat. Immunol.","year":"2000"},{"key":"2025032701004513300_R5","first-page":"8732","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2025032701004513300_R6","first-page":"5610","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2004"},{"key":"2025032701004513300_R7","first-page":"1191","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2025032701004513300_R8","first-page":"269","volume-title":"Nat. Rev. Immunol.","year":"2003"},{"key":"2025032701004513300_R9","first-page":"13759","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2002"},{"key":"2025032701004513300_R10","first-page":"297","volume-title":"Immunity","year":"2002"},{"key":"2025032701004513300_R11","first-page":"1036","volume-title":"Nat. Immunol.","year":"2004"},{"key":"2025032701004513300_R12","first-page":"4400","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032701004513300_R13","first-page":"748","volume-title":"Nat. Med.","year":"2005"},{"key":"2025032701004513300_R14","first-page":"1694","volume-title":"Eur. J. Immunol.","year":"2006"},{"key":"2025032701004513300_R15","first-page":"11730","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2007"},{"key":"2025032701004513300_R16","first-page":"331","volume-title":"Immunity","year":"1995"},{"key":"2025032701004513300_R17","first-page":"619","volume-title":"J. Exp. Med.","year":"2007"},{"key":"2025032701004513300_R18","first-page":"680","volume-title":"Nat. Immunol.","year":"2003"},{"key":"2025032701004513300_R19","first-page":"1797","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2025032701004513300_R20","first-page":"547","volume-title":"J. Exp. Med.","year":"2007"},{"key":"2025032701004513300_R21","first-page":"917","volume-title":"Cell","year":"1994"},{"key":"2025032701004513300_R22","first-page":"3402","volume-title":"J. Immunol.","year":"2001"},{"key":"2025032701004513300_R23","first-page":"153","volume-title":"Infect. Immun.","year":"2002"},{"key":"2025032701004513300_R24","first-page":"109","volume-title":"Immunity","year":"1995"},{"key":"2025032701004513300_R25","first-page":"1531","volume-title":"J. Exp. Med.","year":"1992"},{"key":"2025032701004513300_R26","first-page":"161","volume-title":"J. Immunol. Methods","year":"2006"},{"key":"2025032701004513300_R27","first-page":"107","volume-title":"J. Immunol. Methods","year":"2000"},{"key":"2025032701004513300_R28","first-page":"94","volume-title":"Science","year":"1996"},{"key":"2025032701004513300_R29","first-page":"6791","volume-title":"J. Immunol.","year":"2005"},{"key":"2025032701004513300_R30","first-page":"9125","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1993"},{"key":"2025032701004513300_R31","first-page":"564","volume-title":"Trends Immunol.","year":"2001"},{"key":"2025032701004513300_R32","first-page":"4165","volume-title":"Blood","year":"2004"},{"key":"2025032701004513300_R33","first-page":"4458","volume-title":"J. Immunol.","year":"2006"},{"key":"2025032701004513300_R34","first-page":"1807","volume-title":"J. Exp. Med.","year":"2003"},{"key":"2025032701004513300_R35","first-page":"289","volume-title":"Immunity","year":"2004"},{"key":"2025032701004513300_R36","first-page":"4027","volume-title":"J. Immunol.","year":"2007"},{"key":"2025032701004513300_R37","first-page":"4247","volume-title":"J. Immunol.","year":"2006"},{"key":"2025032701004513300_R38","first-page":"809","volume-title":"Nat. Immunol.","year":"2004"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/5\/2855\/62674633\/zim00508002855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/5\/2855\/62674633\/zim00508002855.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T00:16:32Z","timestamp":1743293792000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/180\/5\/2855\/8023425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,1]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.180.5.2855","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,3]]},"published":{"date-parts":[[2008,3,1]]}}}