{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:24:36Z","timestamp":1769653476266,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fas death pathway is important for lymphocyte homeostasis, but the role of Fas pathway in T cell memory development is not clear. We show that whereas the expansion and contraction of CD8+ T cell response against Listeria monocytogenes were similar for wild-type (WT) and Fas ligand (FasL) mutant mice, the majority of memory CD8+ T cells in FasL mutant mice displayed an effector memory phenotype in the long-term in comparison with the mainly central memory phenotype displayed by memory CD8+ T cells in WT mice. Memory CD8+ T cells in FasL mutant mice expressed reduced levels of IFN-\u03b3 and displayed poor homeostatic and Ag-induced proliferation. Impairment in CD8+ T cell memory in FasL mutant hosts was not due to defective programming or the expression of mutant FasL on CD8+ T cells, but was caused by perturbed cytokine environment in FasL mutant mice. Although adoptively transferred WT memory CD8+ T cells mediated protection against L. monocytogenes in either the WT or FasL mutant hosts, FasL mutant memory CD8+ T cells failed to mediate protection even in WT hosts. Thus, in individuals with mutation in Fas pathway, impairment in the function of the memory CD8+ T cells may increase their susceptibility to recurrent\/latent infections.<\/jats:p>","DOI":"10.4049\/jimmunol.180.5.2933","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:16:52Z","timestamp":1397848612000},"page":"2933-2941","source":"Crossref","is-referenced-by-count":6,"title":["Mutation in the Fas Pathway Impairs CD8+ T Cell Memory"],"prefix":"10.1093","volume":"180","author":[{"given":"Renu","family":"Dudani","sequence":"first","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marsha","family":"Russell","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henk","family":"van Faassen","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Krishnan","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Sad","sequence":"additional","affiliation":[{"name":"National Research Council of Canada, Institute for Biological Sciences , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"2026012809404482000_R1","first-page":"201","volume-title":"Annu. 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