{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:02:31Z","timestamp":1791223351036,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We previously characterized the CTL response of a melanoma patient who experienced tumor regression following vaccination with an ALVAC virus coding for a MAGE-A3 Ag. Whereas anti-vaccine CTL were rare in the blood and inside metastases of this patient, anti-tumor CTL recognizing other tumor Ags, mainly MAGE-C2, were 100 times more frequent in the blood and considerably enriched in metastases following vaccination. In this study we report the analysis of the CTL response of a second melanoma patient who showed a mixed tumor response after vaccination with dendritic cells pulsed with two MAGE-A3 antigenic peptides presented, respectively, by HLA-A1 and HLA-DP4. Anti-MAGE-3.A1 CD8 and anti-MAGE-3.DP4 CD4 T cells became detectable in the blood after vaccination at a frequency of \u223c10\u22125 among the CD8 or CD4 T cells, respectively, and they were slightly enriched in slowly progressing metastases. Additional anti-tumor CTL were present in the blood at a frequency of 2 \u00d7 10\u22124 among the CD8 T cells and, among these, an anti-MAGE-C2 CTL clone was detected only following vaccination and was enriched by &amp;gt;1,000-fold in metastases relative to the blood. The striking similarity of these results with our previous observations further supports the hypothesis that the induction of a few anti-vaccine T cells may prime or restimulate additional anti-tumor T cell clones that are mainly responsible for the tumor regression.<\/jats:p>","DOI":"10.4049\/jimmunol.180.5.3585","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:16:52Z","timestamp":1397863012000},"page":"3585-3593","source":"Crossref","is-referenced-by-count":84,"title":["Vaccination of a Melanoma Patient with Mature Dendritic Cells Pulsed with MAGE-3 Peptides Triggers the Activity of Nonvaccine Anti-Tumor Cells"],"prefix":"10.1093","volume":"180","author":[{"given":"Javier","family":"Carrasco","sequence":"first","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Van Pel","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Neyns","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Universitair Ziekenhuis Brussel , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Lethe\u0301","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Brasseur","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolina","family":"Renkvist","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"van der Bruggen","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"van Baren","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Paulus","sequence":"additional","affiliation":[{"name":"Centre hospitalier Peltzer-La Tourelle , Verviers ,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Thielemans","sequence":"additional","affiliation":[{"name":"Department of Physiology-Immunology, Faculty of Medicine, Vrije Universiteit Brussel , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Boon","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danie\u0300le","family":"Godelaine","sequence":"additional","affiliation":[{"name":"Ludwig Institute for Cancer Research, Christian de Duve Institute, Cellular Genetics Unit, Universite\u0301 Catholique de Louvain , Brussels"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,3,1]]},"reference":[{"key":"2025032701004324300_R1","first-page":"895s","volume-title":"Clin. 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