{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:04:13Z","timestamp":1769652253919,"version":"3.49.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asthma is an allergic disease characterized by chronic airway eosinophilia and pulmonary infiltration of lymphocytes, particularly of the Th2 subtype, macrophages and mast cells. Previous studies have shown a pivotal role for sphingosine kinase (SphK) on various proinflammatory cells, such as lymphocyte and eosinophil migration and mast cell degranulation. We therefore examined the roles of SphK in a murine model of allergic asthma. In mice previously sensitized to OVA, i.p. administration of N,N-dimethylsphingosine (DMS), a potent SphK inhibitor, significantly reduced the total inflammatory cell infiltrate and eosinophilia and the IL-4, IL-5, and eotaxin levels in bronchoalveolar lavage fluid in response to inhaled OVA challenge. In addition, DMS significantly suppressed OVA-induced inflammatory infiltrates and mucus production in the lungs, and airway hyperresponsiveness to methacholine in a dose-dependent manner. OVA-induced lymphocyte proliferation and IL-4 and IL-5 secretion were reduced in thoracic lymph node cultures from DMS-treated mice. Moreover, similar reduction in inflammatory infiltrates, bronchoalveolar lavage, IL-4, IL-5, eotaxin, and serum OVA-specific IgE levels was observed in mice with SphK1 knock-down via small interfering RNA approach. Together, these data demonstrate the therapeutic potential of SphK modulation in allergic airways disease.<\/jats:p>","DOI":"10.4049\/jimmunol.180.6.4323","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T19:47:10Z","timestamp":1397850430000},"page":"4323-4329","source":"Crossref","is-referenced-by-count":80,"title":["The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma"],"prefix":"10.1093","volume":"180","author":[{"given":"Wen-Qi","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore, Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong Heng","family":"Goh","sequence":"additional","affiliation":[{"name":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore, Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhang","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore, Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W S Fred","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore, Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alirio J","family":"Melendez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore, Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard P","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore ,","place":["Singapore, Republic of Singapore"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,3,15]]},"reference":[{"key":"2026012809191394700_R1","first-page":"225","volume-title":"J. 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