{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:25:28Z","timestamp":1792650328391,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The intestinal tract of adult mice is naturally resistant to infection by Shigella, the causative agent of bacillary dysentery in humans. Conversely, newborn mice are highly susceptible to intragastric Shigella infection and develop inflammatory lesions of the jejunal mucosa, very similar to those observed in the colon of dysenteric patients. However, the susceptibility period is short and one week after birth, animals have acquired a status of resistance characteristic of adult animals. To identify the developmental changes controlling the switch from disease susceptibility to resistance, we performed global gene expression analysis on noninfected and infected intestinal tissues taken from 4-day- and 7-day-old animals. Transcriptomic analysis of 4-day-old mice infected with the invasive Shigella strain showed a profile reflecting a strong inflammatory response with no evidence for retro-control, suggesting that the invasive process had occurred, whereas inflammation had been controlled after infection with the noninvasive strain. Differences in gene expression profiles between noninfected 4-day- and 7-day-old mice corresponded mainly to genes encoding anti-microbial peptides and proteases, suggesting that these molecules could be candidates for host antimicrobial resistance in the course of shigellosis. Indeed, expression of genes specific of Paneth cells was higher in 7-day- than in 4-day-old mice, and histological analysis indicated that Paneth cells were present only at day 7. Finally, using Sox9flox\/flox-vil-cre mice, we showed that depletion of Paneth cells restored the susceptibility to Shigella of 7-day-old mice, clearly indicating that Paneth cells development is crucial for the clearance of intestinal infection.<\/jats:p>","DOI":"10.4049\/jimmunol.180.7.4924","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:12:56Z","timestamp":1397862776000},"page":"4924-4930","source":"Crossref","is-referenced-by-count":53,"title":["Maturation of Paneth Cells Induces the Refractory State of Newborn Mice to <i>Shigella<\/i> Infection"],"prefix":"10.1093","volume":"180","author":[{"given":"Maria-Isabel","family":"Fernandez","sequence":"first","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, De\u0301partement de Biologie Cellulaire et Infection , Paris ,","place":["France"]},{"name":"Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U786 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u0301atrice","family":"Regnault","sequence":"additional","affiliation":[{"name":"Plateforme Puces a\u0300 ADN, Institut Pasteur , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce\u0301line","family":"Mulet","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, De\u0301partement de Biologie Cellulaire et Infection , Paris ,","place":["France"]},{"name":"Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U786 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Tanguy","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, De\u0301partement de Biologie Cellulaire et Infection , Paris ,","place":["France"]},{"name":"Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U786 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Jay","sequence":"additional","affiliation":[{"name":"Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U661, De\u0301partement d\u2019Oncologie Cellulaire et Mole\u0301culaire, Institut de Ge\u0301nomique Fonctionnelle, Centre National de la Recherche Scientifique Unite\u0301 Mixte de Recherche 5203, Universite\u0301 de Montpellier I et Universite\u0301 de Montpellier II , Montpellier ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe J","family":"Sansonetti","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, De\u0301partement de Biologie Cellulaire et Infection , Paris ,","place":["France"]},{"name":"Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U786 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Pe\u0301dron","sequence":"additional","affiliation":[{"name":"Unite\u0301 de Pathoge\u0301nie Microbienne Mole\u0301culaire, De\u0301partement de Biologie Cellulaire et Infection , Paris ,","place":["France"]},{"name":"Unite\u0301 Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U786 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2025033118421398300_R1","first-page":"1722","volume-title":"Science","year":"2001"},{"key":"2025033118421398300_R2","first-page":"739","volume-title":"Immunity","year":"2003"},{"key":"2025033118421398300_R3","first-page":"136","volume-title":"J. Infect. Dis.","year":"2005"},{"key":"2025033118421398300_R4","first-page":"1201","volume-title":"EMBO Rep.","year":"2005"},{"key":"2025033118421398300_R5","first-page":"4197","volume-title":"J. Immunol.","year":"2004"},{"key":"2025033118421398300_R6","first-page":"481","volume-title":"Cell. Microbiol.","year":"2003"},{"key":"2025033118421398300_R7","first-page":"3214","volume-title":"J. Immunol.","year":"2000"},{"key":"2025033118421398300_R8","first-page":"33878","volume-title":"J. Biol. Chem.","year":"2003"},{"key":"2025033118421398300_R9","first-page":"249","volume-title":"Biostatistics","year":"2003"},{"key":"2025033118421398300_R10","first-page":"31","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2001"},{"key":"2025033118421398300_R11","first-page":"522","volume-title":"Nature","year":"2003"},{"key":"2025033118421398300_R12","first-page":"1126","volume-title":"Science","year":"2006"},{"key":"2025033118421398300_R13","first-page":"1802","volume-title":"Gut","year":"2005"},{"key":"2025033118421398300_R14","first-page":"786","volume-title":"J. Clin. Pathol.","year":"1986"},{"key":"2025033118421398300_R15","first-page":"839","volume-title":"N. Engl. J. Med.","year":"1995"},{"key":"2025033118421398300_R16","first-page":"303","volume-title":"Clin. Exp. Immunol.","year":"2004"},{"key":"2025033118421398300_R17","first-page":"407","volume-title":"Int. J. Exp. Pathol.","year":"1991"},{"key":"2025033118421398300_R18","first-page":"6143","volume-title":"Infect. Immun.","year":"2005"},{"key":"2025033118421398300_R19","first-page":"1","volume-title":"Trends Immunol.","year":"2007"},{"key":"2025033118421398300_R20","first-page":"635","volume-title":"J. Cell Biol.","year":"2007"},{"key":"2025033118421398300_R21","first-page":"539","volume-title":"Gastroenterology","year":"2007"},{"key":"2025033118421398300_R22","first-page":"2001","volume-title":"Antimicrob. Agents Chemother.","year":"1997"},{"key":"2025033118421398300_R23","first-page":"18129","volume-title":"Proc. Natl. Acad. Sci. USA","year":"2005"},{"key":"2025033118421398300_R24","first-page":"2777","volume-title":"J. Immunol.","year":"1999"},{"key":"2025033118421398300_R25","first-page":"2234","volume-title":"Infect. Immun.","year":"2007"},{"key":"2025033118421398300_R26","first-page":"973","volume-title":"J. Exp. Med.","year":"2006"},{"key":"2025033118421398300_R27","first-page":"10335","volume-title":"Proc. Natl. Acad. Sci. USA","year":"1994"},{"key":"2025033118421398300_R28","first-page":"G197","volume-title":"Am. J. Physiol.","year":"1997"},{"key":"2025033118421398300_R29","first-page":"1815","volume-title":"J. Clin. Invest.","year":"1998"},{"key":"2025033118421398300_R30","first-page":"278","volume-title":"J. Infect. Chemother.","year":"2003"},{"key":"2025033118421398300_R31","first-page":"113","volume-title":"Science","year":"1999"},{"key":"2025033118421398300_R32","first-page":"1464","volume-title":"J. Infect. Dis.","year":"2006"},{"key":"2025033118421398300_R33","first-page":"512","volume-title":"J. Clin. Pathol.","year":"1998"},{"key":"2025033118421398300_R34","first-page":"42","volume-title":"Chem. Immunol. Allergy.","year":"2005"},{"key":"2025033118421398300_R35","first-page":"500","volume-title":"J. Leukocyte Biol.","year":"2006"},{"key":"2025033118421398300_R36","first-page":"731","volume-title":"Science","year":"2005"},{"key":"2025033118421398300_R37","first-page":"1245","volume-title":"J. Immunol.","year":"2007"},{"key":"2025033118421398300_R38","first-page":"70","volume-title":"Semin. Immunol.","year":"2007"}],"container-title":["The Journal of Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/7\/4924\/62819347\/zim00708004924.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jimmunol\/article-pdf\/180\/7\/4924\/62819347\/zim00708004924.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T21:54:51Z","timestamp":1743458091000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jimmunol\/article\/180\/7\/4924\/8021570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.4049\/jimmunol.180.7.4924","relation":{},"ISSN":["0022-1767","1550-6606"],"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,4]]},"published":{"date-parts":[[2008,4,1]]}}}