{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:31:35Z","timestamp":1791174695310,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>IL 4 receptor \u03b1 (IL-4R\u03b1) expression by non-bone marrow (BM)-derived cells is required to protect hosts against several parasitic helminth species. In contrast, we demonstrate that IL-4R\u03b1 expression by BM-derived cells is both necessary and sufficient to prevent Schistosoma mansoni-infected mice from developing severe inflammation directed against parasite ova, whereas IL-4R\u03b1 expression by non-BM-derived cells is neither necessary nor sufficient. Chimeras that express IL-4R\u03b1 only on non-BM-derived cells still produce Th2 cytokines, but overproduce IL-12p40, TNF, and IFN-\u03b3, fail to generate alternatively activated macrophages, and develop endotoxemia and severe hepatic and intestinal pathology. In contrast, chimeras that express IL-4R\u03b1 only on BM-derived cells have extended survival, even though the granulomas that they develop around parasite eggs are small and devoid of collagen. These observations identify distinct roles for IL-4\/IL-13 responsive cell lineages during schistosomiasis: IL-4R\u03b1-mediated signaling in non-BM-derived cells regulates granuloma size and fibrosis, whereas signaling in BM-derived cells suppresses parasite egg-driven inflammation within the liver and intestine.<\/jats:p>","DOI":"10.4049\/jimmunol.180.7.4948","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:12:56Z","timestamp":1397862776000},"page":"4948-4955","source":"Crossref","is-referenced-by-count":33,"title":["IL-4R\u03b1 Expression by Bone Marrow-Derived Cells Is Necessary and Sufficient for Host Protection against Acute Schistosomiasis"],"prefix":"10.1093","volume":"180","author":[{"given":"De\u2019Broski R","family":"Herbert","sequence":"first","affiliation":[{"name":"Research Service (151), Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana","family":"Orekov","sequence":"additional","affiliation":[{"name":"Research Service (151), Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Perkins","sequence":"additional","affiliation":[{"name":"Research Service (151), Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc E","family":"Rothenberg","sequence":"additional","affiliation":[{"name":"Division of Allergy and Immunology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred D","family":"Finkelman","sequence":"additional","affiliation":[{"name":"Research Service (151), Cincinnati Veterans Administration Medical Center , Cincinnati, OH 45220"},{"name":"Division of Immunology, University of Cincinnati College of Medicine , Cincinnati, OH 45267"},{"name":"Division of Immunobiology, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2025033118424576400_R1","first-page":"507","volume-title":"J. 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