{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:06:34Z","timestamp":1791331594509,"version":"4.3.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The chemokines (CKs) CXCL13, CCL21, and CXCL12 are known to play differential roles in the organization of the lymphoid tissues and the development of lymphoid malignancies. We investigated the expression of these CKs and their receptors in the salivary glands of Sjogren\u2019s syndrome patients with lymphoepithelial lesions (lymphoepithelial sialadenitis or LESA) and in MALT lymphoma to understand their involvement in salivary gland lymphomagenesis. We demonstrate that within salivary glands with LESA and MALT lymphoma the lymphoid CKs CXCL13 and CCL21 are selectively associated with areas of reactive lymphoid proliferation, whereas no significant expression of these molecules was detected in the malignant lymphoid aggregate. Conversely, CXCL12 was observed predominantly in infiltrated ducts and malignant B cells. Accordingly, CXCL13 and CCL21 transcript levels were significantly increased in LESA samples while CXCL12 levels were increased in MALT lymphoma and isolated tumor cells. Low levels of CK receptors were detected on lymphoma-extracted lymphocytes, suggesting down-regulation in the abundance of ligands. Our findings suggest that in salivary gland MALT lymphoma the lymphoid CKs CXCL13 and CCL21 are directly implicated in the organization of ectopic reactive lymphoid tissue, whereas CXCL12 is associated with the infiltrated epithelium and malignant B cell component and is possibly involved in the regulation of malignant B cell survival.<\/jats:p>","DOI":"10.4049\/jimmunol.180.7.5130","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T23:12:56Z","timestamp":1397862776000},"page":"5130-5140","source":"Crossref","is-referenced-by-count":185,"title":["CXCL13, CCL21, and CXCL12 Expression in Salivary Glands of Patients with Sjo\u0308gren\u2019s Syndrome and MALT Lymphoma: Association with Reactive and Malignant Areas of Lymphoid Organization"],"prefix":"10.1093","volume":"180","author":[{"given":"Francesca","family":"Barone","sequence":"first","affiliation":[{"name":"Divisione di Reumatologia Dipartimento di Clinica e Terapia Applicata, Universita\u0300 La Sapienza Roma , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Bombardieri","sequence":"additional","affiliation":[{"name":"Divisione di Reumatologia Dipartimento di Clinica e Terapia Applicata, Universita\u0300 La Sapienza Roma , Rome ,","place":["Italy"]},{"name":"Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, St. Bartholomew\u2019s and Royal London School of Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela Maria","family":"Rosado","sequence":"additional","affiliation":[{"name":"Research Center Ospedale Pediatrico Bambino Gesu\u0300 , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Roger","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine at Guy\u2019s, St. Thomas and King\u2019s College Dental Institute , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"Challacombe","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Oral Medicine at Guy\u2019s, St. Thomas and King\u2019s College Dental Institute , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"De Vita","sequence":"additional","affiliation":[{"name":"Clinica di Reumatologia, Department of Experimental and Clinical Pathology and Medicine, Universita\u0300 di Udine, Azienda Ospedaliero-Universitaria , Udine ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Carsetti","sequence":"additional","affiliation":[{"name":"Research Center Ospedale Pediatrico Bambino Gesu\u0300 , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Division of Immunology, Infection and Inflammatory Diseases at Guy\u2019s, St. Thomas and King\u2019s College School of Medicine, King\u2019s College , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Valesini","sequence":"additional","affiliation":[{"name":"Divisione di Reumatologia Dipartimento di Clinica e Terapia Applicata, Universita\u0300 La Sapienza Roma , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costantino","family":"Pitzalis","sequence":"additional","affiliation":[{"name":"Centre for Experimental Medicine and Rheumatology, John Vane Science Centre, William Harvey Research Institute, St. Bartholomew\u2019s and Royal London School of Medicine , London ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2025033118414266800_R1","first-page":"1788","volume-title":"Eur. 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