{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:48:05Z","timestamp":1790855285475,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>IL-7 is essential for the survival of naive and memory T cells, and IL-7 receptor \u03b1-chain (IL-7R\u03b1) expression is dynamically regulated in activated CD8 T cells during acute viral and bacterial infections. Most virus-specific CD8 T cells become IL-7R\u03b1low and are relatively short-lived, but some escape IL-7R\u03b1 repression (referred to as IL-7R\u03b1high memory precursor effector cells) and preferentially enter the memory CD8 T cell pool. How antiviral effector CD8 T cells regulate IL-7R\u03b1 expression in an \u201con and off\u201d fashion remains to be characterized. During lymphocytic choriomeningitis virus infection, we found that opposing actions of the transcription factors GABP\u03b1 (GA binding protein \u03b1) and Gfi-1 (growth factor independence 1) control IL-7R\u03b1 expression in effector CD8 T cells. Specifically, GABP\u03b1 was required for IL-7R\u03b1 expression in memory precursor effector cells, and this correlated with hyperacetylation of the Il7ra promoter. In contrast, Gfi-1 was required for stable IL-7R\u03b1 repression in effector CD8 T cells and acted by antagonizing GABP\u03b1 binding and recruiting histone deacetylase 1, which deacetylated the Il7ra promoter. Thus, Il7ra promoter acetylation and activity was dependent on the reciprocal binding of GABP\u03b1 and Gfi-1, and these data provide a biochemical mechanism for the generation of stable IL-7R\u03b1high and IL-7R\u03b1low states in virus-specific effector CD8 T cells.<\/jats:p>","DOI":"10.4049\/jimmunol.180.8.5309","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:52:42Z","timestamp":1397847162000},"page":"5309-5319","source":"Crossref","is-referenced-by-count":76,"title":["Formation of IL-7R\u03b1high and IL-7R\u03b1low CD8 T Cells during Infection Is Regulated by the Opposing Functions of GABP\u03b1 and Gfi-1"],"prefix":"10.1093","volume":"180","author":[{"given":"Anmol","family":"Chandele","sequence":"first","affiliation":[{"name":"Department of Immunobiology, Yale Medical School , New Haven, CT 06511"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil S","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale Medical School , New Haven, CT 06511"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E","family":"Paul","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Institute of Allergy and Infectious Diseases and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J","family":"Leonard","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M","family":"Kaech","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, Yale Medical School , New Haven, CT 06511"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"2026012809151916000_R1","first-page":"144","volume-title":"Nat. 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