{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:53:41Z","timestamp":1782975221475,"version":"3.54.5"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Numerous studies have demonstrated that targeting Ag to Fc receptors (FcR) on APCs can enhance humoral and cellular immunity. However, studies are lacking that examine both the use of FcR-targeting in generating immune protection against infectious agents and the use of FcRs in the induction of mucosal immunity. Francisella tularensis is a category A intracellular mucosal pathogen. Thus, intense efforts are underway to develop a vaccine against this organism. We hypothesized that protection against mucosal infection with F. tularensis would be significantly enhanced by targeting inactivated F. tularensis live vaccine strain (iFt) to FcRs at mucosal sites, via intranasal immunization with mAb-iFt complexes. These studies demonstrate for the first time that: 1) FcR-targeted immunogen enhances immunogen-specific IgA production and protection against subsequent infection in an IgA-dependent manner, 2) Fc\u03b3R and neonatal FcR are crucial to this protection, and 3) inactivated F. tularensis, when targeted to FcRs, enhances protection against the highly virulent SchuS4 strain of F. tularensis, a category A biothreat agent. In summary, these studies show for the first time the use of FcRs as a highly effective vaccination strategy against a highly virulent mucosal intracellular pathogen.<\/jats:p>","DOI":"10.4049\/jimmunol.180.8.5548","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:52:42Z","timestamp":1397847162000},"page":"5548-5557","source":"Crossref","is-referenced-by-count":92,"title":["Utilization of Fc Receptors as a Mucosal Vaccine Strategy against an Intracellular Bacterium,\n                    <i>Francisella tularensis<\/i>"],"prefix":"10.1093","volume":"180","author":[{"given":"Deepak B","family":"Rawool","sequence":"first","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine","family":"Bitsaktsis","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane R","family":"Gosselin","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Lin","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin V","family":"Kurkure","sequence":"additional","affiliation":[{"name":"Nagpur Veterinary College, Maharashtra Animal and Fishery Sciences University , Nagpur ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W","family":"Metzger","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund J","family":"Gosselin","sequence":"additional","affiliation":[{"name":"Center for Immunology and Microbial Disease, Albany Medical College , Albany, NY 12208"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"2026012809212230500_R1","first-page":"417","volume-title":"Immunol. 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