{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T02:22:39Z","timestamp":1769653359202,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Protein kinase C-\u03b8 (PKC-\u03b8) is essential for the activation of T cells in autoimmune disorders, but not in viral infections. To study the role of PKC-\u03b8 in bacterial infections, PKC-\u03b8\u2212\/\u2212 and wild-type mice were infected with Listeria monocytogenes (LM). In primary and secondary listeriosis, the numbers of LM-specific CD8 and CD4 T cells were drastically reduced in PKC-\u03b8\u2212\/\u2212 mice, resulting in increased CFUs in spleen and liver of both PKC-\u03b8\u2212\/\u2212 C57BL\/6 and BALB\/c mice. Furthermore, immunization with peptide-loaded wild-type dendritic cells induced LM-specific CD4 and CD8 T cells in wild-type but not in PKC-\u03b8\u2212\/\u2212 mice. In listeriosis, transfer of wild-type T cells into PKC-\u03b8\u2212\/\u2212 mice resulted in a normal control of Listeria, and, additionally, a selective expression of PKC-\u03b8 in LM-specific T cells was sufficient to drive a normal proliferation and survival of these T cells in LM-infected PKC-\u03b8\u2212\/\u2212 recipients, illustrating a cell-autonomous function of PKC-\u03b8 in LM-specific T cells. Conversely, adoptively transferred PKC-\u03b8\u2212\/\u2212 T cells were partially rescued from cell death and proliferated in LM-infected wild-type recipients, demonstrating that a PKC-\u03b8 deficiency of LM-specific T cells can be partially compensated for by a wild-type environment. Additionally, in vitro experiments showed that only the addition of IL-2, but not an inhibition of caspase-3, induced proliferation and prevented death of PKC-\u03b8\u2212\/\u2212 T cells stimulated with LM-infected wild-type dendritic cells, further demonstrating that the impaired proliferation and survival of PKC-\u03b8\u2212\/\u2212 T cells in listeriosis is not intrinsically fixed and can be experimentally improved.<\/jats:p>","DOI":"10.4049\/jimmunol.180.8.5601","type":"journal-article","created":{"date-parts":[[2014,4,18]],"date-time":"2014-04-18T18:52:42Z","timestamp":1397847162000},"page":"5601-5612","source":"Crossref","is-referenced-by-count":15,"title":["Protein Kinase C-\u03b8 Critically Regulates the Proliferation and Survival of Pathogen-Specific T Cells in Murine Listeriosis"],"prefix":"10.1093","volume":"180","author":[{"given":"Monika","family":"Sakowicz-Burkiewicz","sequence":"first","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopala","family":"Nishanth","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Helmuth","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Dro\u0308gemu\u0308ller","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk H","family":"Busch","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universita\u0308t Mu\u0308nchen , Munich ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Utermo\u0308hlen","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Immunologie und Hygiene, Klinikum der Universita\u0308t zu Ko\u0308ln , Cologne ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Naumann","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Experimentelle Innere Medizin, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Deckert","sequence":"additional","affiliation":[{"name":"Abteilung fu\u0308r Neuropathologie, Klinikum der Universita\u0308t zu Ko\u0308ln , Cologne ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Schlu\u0308ter","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Medizinische Mikrobiologie, Otto-von-Guericke Universita\u0308t Magdeburg , Magdeburg ,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2008,4,15]]},"reference":[{"key":"2026012809144834500_R1","first-page":"263","volume-title":"Cell. 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