{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:47:10Z","timestamp":1780055230168,"version":"3.54.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The substantial morbidity and mortality caused by invasive fungal pathogens, including Cryptococcus neoformans, necessitates increased understanding of protective immune responses against these infections. Our previous work using murine models of cryptococcal lung infection demonstrated that dendritic cells (DCs) orchestrate critical transitions from innate to adaptive immunity and that IL-10 signaling blockade improves fungal clearance. To further understand interrelationships among IL-10 production, fungal clearance, and the effect of IL-10 on lung DCs, we performed a comparative temporal analysis of cryptococcal lung infection in wild type C57BL\/6J mice (designated IL-10+\/+) and IL-10\u2212\/\u2212 mice inoculated intratracheally with C. neoformans (strain 52D). Early and sustained IL-10 production by lung leukocytes was associated with persistent infection in IL-10+\/+ mice, whereas fungal clearance was improved in IL-10\u2212\/\u2212 mice during the late adaptive phase of infection. Numbers of monocyte-derived DCs, T cells, and alveolar and exudate macrophages were increased in lungs of IL-10\u2212\/\u2212 versus IL-10+\/+ mice concurrent with evidence of enhanced DC type-1, Th1\/Th17 CD4 cell, and classical macrophage activation. Bone marrow\u2013derived DCs stimulated with cryptococcal mannoproteins, a component of the fungal capsule, upregulated expression of IL-10 and IL-10R, which promoted DC type-2 activation in an autocrine manner. Thus, our findings implicate fungus-triggered autocrine IL-10 signaling and DC type-2 activation as important contributors to the development of nonprotective immune effector responses, which characterize persistent cryptococcal lung infection. Collectively, this study informs and strengthens the rationale for IL-10 signaling blockade as a novel treatment for fungal infections.<\/jats:p>","DOI":"10.4049\/jimmunol.1800070","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T15:25:23Z","timestamp":1533914723000},"page":"2004-2015","source":"Crossref","is-referenced-by-count":25,"title":["Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection"],"prefix":"10.1093","volume":"201","author":[{"given":"Seagal","family":"Teitz-Tennenbaum","sequence":"first","affiliation":[{"name":"Research Service, Ann Arbor Veterans Affairs Health System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P","family":"Viglianti","sequence":"additional","affiliation":[{"name":"Research Service, Ann Arbor Veterans Affairs Health System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A","family":"Roussey","sequence":"additional","affiliation":[{"name":"Research Service, Ann Arbor Veterans Affairs Health System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-3064","authenticated-orcid":false,"given":"Stuart M","family":"Levitz","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Massachusetts Medical Center , Worcester, MA 01605"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-0843","authenticated-orcid":false,"given":"Michal A","family":"Olszewski","sequence":"additional","affiliation":[{"name":"Research Service, Ann Arbor Veterans Affairs Health System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Graduate Program in Immunology, University of Michigan Health System , Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J","family":"Osterholzer","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Graduate Program in Immunology, University of Michigan Health System , Ann Arbor, MI 48109"},{"name":"Pulmonary Section Medical Service, Ann Arbor Veterans Affairs Health System, Department of Veterans Affairs Health System , Ann Arbor, MI 48105"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"2025030417572915600_r1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/clinids\/13.6.1163","article-title":"The ecology of Cryptococcus neoformans and the epidemiology of cryptococcosis","volume":"13","author":"Levitz","year":"1991","journal-title":"Rev. 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Med."},{"key":"2025030417572915600_r5","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2217\/fmb.10.93","article-title":"Mechanisms of cryptococcal virulence and persistence","volume":"5","author":"Olszewski","year":"2010","journal-title":"Future Microbiol."},{"key":"2025030417572915600_r6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1086\/313992","article-title":"Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand","volume":"31","author":"Chen","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"2025030417572915600_r7","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1567-1364.2010.00648.x","article-title":"Prevalence of the VNIc genotype of Cryptococcus neoformans in non-HIV-associated cryptococcosis in the Republic of Korea","volume":"10","author":"Choi","year":"2010","journal-title":"FEMS Yeast Res."},{"key":"2025030417572915600_r8","doi-asserted-by":"crossref","first-page":"e6854","DOI":"10.1371\/journal.pone.0006854","article-title":"Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis","volume":"4","author":"Wozniak","year":"2009","journal-title":"PLoS One"},{"key":"2025030417572915600_r9","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.2353\/ajpath.2009.090530","article-title":"Robust Th1 and Th17 immunity supports pulmonary clearance but cannot prevent systemic dissemination of highly virulent Cryptococcus neoformans H99","volume":"175","author":"Zhang","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2025030417572915600_r10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1128\/IAI.01477-13","article-title":"Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production","volume":"82","author":"Murdock","year":"2014","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r11","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1128\/IAI.01270-10","article-title":"Effect of cytokine interplay on macrophage polarization during chronic pulmonary infection with Cryptococcus neoformans","volume":"79","author":"Arora","year":"2011","journal-title":"Infect. 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Immunol."},{"key":"2025030417572915600_r19","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1128\/IAI.00047-11","article-title":"Interleukin-10 and immunity against prokaryotic and eukaryotic intracellular pathogens","volume":"79","author":"Cyktor","year":"2011","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r20","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1172\/JCI118290","article-title":"Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance","volume":"96","author":"Berg","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2025030417572915600_r21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/eji.200939592","article-title":"Monocytes\/macrophages and\/or neutrophils are the target of IL-10 in the LPS endotoxemia model","volume":"40","author":"Pils","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"2025030417572915600_r22","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1002\/eji.200636012","article-title":"Interleukin-10 derived from macrophages and\/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA","volume":"36","author":"Siewe","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"2025030417572915600_r23","doi-asserted-by":"crossref","first-page":"798","DOI":"10.4049\/jimmunol.157.2.798","article-title":"In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha","volume":"157","author":"Gazzinelli","year":"1996","journal-title":"J. Immunol."},{"key":"2025030417572915600_r24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1084\/jem.20062175","article-title":"Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection","volume":"204","author":"Jankovic","year":"2007","journal-title":"J. Exp. Med."},{"key":"2025030417572915600_r25","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.4049\/jimmunol.166.10.6323","article-title":"IL-10-deficient mice demonstrate multiple organ failure and increased mortality during Escherichia coli peritonitis despite an accelerated bacterial clearance","volume":"166","author":"Sewnath","year":"2001","journal-title":"J. Immunol."},{"key":"2025030417572915600_r26","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.4049\/jimmunol.0900657","article-title":"IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challenge","volume":"182","author":"McKinstry","year":"2009","journal-title":"J. Immunol."},{"key":"2025030417572915600_r27","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1128\/JVI.02408-09","article-title":"A detrimental effect of interleukin-10 on protective pulmonary humoral immunity during primary influenza A virus infection","volume":"84","author":"Sun","year":"2010","journal-title":"J. Virol."},{"key":"2025030417572915600_r28","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/nm1492","article-title":"Interleukin-10 determines viral clearance or persistence in vivo","volume":"12","author":"Brooks","year":"2006","journal-title":"Nat. Med."},{"key":"2025030417572915600_r29","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1128\/IAI.67.12.6314-6320.1999","article-title":"Cytokine profiles of AIDS patients are similar to those of mice with disseminated Cryptococcus neoformans infection","volume":"67","author":"Lortholary","year":"1999","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.trim.2006.03.009","article-title":"Systemic and cerebrospinal fluid T-helper cytokine responses in organ transplant recipients with Cryptococcus neoformans infection","volume":"16","author":"Singh","year":"2006","journal-title":"Transpl. Immunol."},{"key":"2025030417572915600_r31","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1093\/infdis\/jiw007","article-title":"A glucuronoxylomannan-associated immune signature, characterized by monocyte deactivation and an increased interleukin 10 level, is a predictor of death in Cryptococcal Meningitis","volume":"213","author":"Scriven","year":"2016","journal-title":"J. Infect. Dis."},{"key":"2025030417572915600_r32","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4049\/jimmunol.174.2.1027","article-title":"Distinct roles for IL-4 and IL-10 in regulating T2 immunity during allergic bronchopulmonary mycosis","volume":"174","author":"Hernandez","year":"2005","journal-title":"J. Immunol."},{"key":"2025030417572915600_r33","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.4049\/jimmunol.1400650","article-title":"Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection","volume":"193","author":"Murdock","year":"2014","journal-title":"J. Immunol."},{"key":"2025030417572915600_r34","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.4049\/jimmunol.168.6.2872","article-title":"Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors","volume":"168","author":"Mansour","year":"2002","journal-title":"J. Immunol."},{"key":"2025030417572915600_r35","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.4049\/jimmunol.1501512","article-title":"Local GM-CSF-dependent differentiation and activation of pulmonary dendritic cells and macrophages protect against progressive cryptococcal lung infection in mice","volume":"196","author":"Chen","year":"2016","journal-title":"J. Immunol."},{"key":"2025030417572915600_r36","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1165\/rcmb.2013-0086MA","article-title":"Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung","volume":"49","author":"Misharin","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"2025030417572915600_r37","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.2217\/fmb.15.92","article-title":"Role of dendritic cell-pathogen interactions in the immune response to pulmonary cryptococcal infection","volume":"10","author":"Eastman","year":"2015","journal-title":"Future Microbiol."},{"key":"2025030417572915600_r38","doi-asserted-by":"crossref","first-page":"932","DOI":"10.2353\/ajpath.2009.080673","article-title":"Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung","volume":"174","author":"Osterholzer","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2025030417572915600_r39","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ajpath.2010.11.006","article-title":"Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection","volume":"178","author":"Osterholzer","year":"2011","journal-title":"Am. J. Pathol."},{"key":"2025030417572915600_r40","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1128\/IAI.00297-09","article-title":"Cytokine signaling regulates the outcome of intracellular macrophage parasitism by Cryptococcus neoformans. [Published erratum appears in 2016. Infect. Immun. 84: 3656.]","volume":"77","author":"Voelz","year":"2009","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r41","doi-asserted-by":"crossref","first-page":"e00264-13","DOI":"10.1128\/mBio.00264-13","article-title":"Macrophage M1\/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection","volume":"4","author":"Davis","year":"2013","journal-title":"MBio"},{"key":"2025030417572915600_r42","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","article-title":"Nitric oxide and macrophage function","volume":"15","author":"MacMicking","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417572915600_r43","doi-asserted-by":"crossref","first-page":"10422","DOI":"10.1073\/pnas.181331398","article-title":"Molecular characterization of a mannoprotein with homology to chitin deacetylases that stimulates T cell responses to Cryptococcus neoformans","volume":"98","author":"Levitz","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2025030417572915600_r44","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/infdis\/159.1.116","article-title":"T cell response to soluble cryptococcal antigens after recovery from cryptococcal infection","volume":"159","author":"Hoy","year":"1989","journal-title":"J. Infect. Dis."},{"key":"2025030417572915600_r45","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.4049\/jimmunol.159.6.2979","article-title":"Induction of TNF-alpha in human peripheral blood mononuclear cells by the mannoprotein of Cryptococcus neoformans involves human mannose binding protein","volume":"159","author":"Chaka","year":"1997","journal-title":"J. Immunol."},{"key":"2025030417572915600_r46","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1128\/IAI.69.5.2808-2814.2001","article-title":"Role of mannoprotein in induction and regulation of immunity to Cryptococcus neoformans","volume":"69","author":"Pietrella","year":"2001","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r47","first-page":"191","article-title":"The molecular basis of IL-10 function: from receptor structure to the onset of signaling","volume":"380","author":"Walter","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"2025030417572915600_r48","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"2025030417572915600_r49","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cytogfr.2010.09.002","article-title":"Biology of interleukin-10","volume":"21","author":"Sabat","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"2025030417572915600_r50","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1128\/IAI.67.2.670-674.1999","article-title":"Early resistance of interleukin-10 knockout mice to acute systemic candidiasis","volume":"67","author":"Vazquez-Torres","year":"1999","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r51","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1128\/IAI.67.6.3087-3095.1999","article-title":"Increased antimycobacterial immunity in interleukin-10-deficient mice","volume":"67","author":"Murray","year":"1999","journal-title":"Infect. 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Immun."},{"key":"2025030417572915600_r55","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1128\/IAI.73.3.1788-1796.2005","article-title":"The gamma interferon receptor is required for the protective pulmonary inflammatory response to Cryptococcus neoformans","volume":"73","author":"Chen","year":"2005","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/nri978","article-title":"Alternative activation of macrophages","volume":"3","author":"Gordon","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"2025030417572915600_r57","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1002\/eji.201444963","article-title":"CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection","volume":"44","author":"Schulze","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"2025030417572915600_r58","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4049\/jimmunol.1501871","article-title":"Regulatory T cell induction and retention in the lungs drives suppression of detrimental type 2 Th cells during pulmonary cryptococcal infection","volume":"196","author":"Wiesner","year":"2016","journal-title":"J. Immunol."},{"key":"2025030417572915600_r59","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.4049\/jimmunol.1700840","article-title":"Anti-PD-1 antibody treatment promotes clearance of persistent cryptococcal lung infection in mice","volume":"199","author":"Roussey","year":"2017","journal-title":"J. Immunol."},{"key":"2025030417572915600_r60","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1128\/IAI.73.1.39-49.2005","article-title":"Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells","volume":"73","author":"Herring","year":"2005","journal-title":"Infect. Immun."},{"key":"2025030417572915600_r61","doi-asserted-by":"crossref","first-page":"5485","DOI":"10.1128\/IAI.70.10.5485-5493.2002","article-title":"Purification and characterization of a second immunoreactive mannoprotein from Cryptococcus neoformans that stimulates T-Cell responses","volume":"70","author":"Huang","year":"2002","journal-title":"Infect. 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