{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:01:55Z","timestamp":1768690915891,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Apoptosis of CD8 T cells is an essential mechanism that maintains immune system homeostasis, prevents autoimmunity, and reduces immunopathology. CD8 T cell death also occurs early during the response to both inflammation and costimulation blockade (CoB). In this article, we studied the effects of a combined deficiency of Fas (extrinsic pathway) and Bim (intrinsic pathway) on early T cell attrition in response to lymphocytic choriomeningitis virus infection and during CoB during transplantation. Loss of Fas and Bim function in Bcl2l11\u2212\/\u2212Faslpr\/lpr mice inhibited apoptosis of T cells and prevented the early T cell attrition resulting from lymphocytic choriomeningitis virus infection. Bcl2l11\u2212\/\u2212Faslpr\/lpr mice were also resistant to prolonged allograft survival induced by CoB targeting the CD40-CD154 pathway. These results demonstrate that both extrinsic and intrinsic apoptosis pathways function concurrently to regulate T cell homeostasis during the early stages of immune responses and allograft survival during CoB.<\/jats:p>","DOI":"10.4049\/jimmunol.1800278","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T20:55:14Z","timestamp":1546635314000},"page":"647-651","source":"Crossref","is-referenced-by-count":3,"title":["Cutting Edge: Early Attrition of Memory T Cells during Inflammation and Costimulation Blockade Is Regulated Concurrently by Proapoptotic Proteins Fas and Bim"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2464-4711","authenticated-orcid":false,"given":"Sonal","family":"Jangalwe","sequence":"first","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun N","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"IBM Watson Health , Cambridge, MA 02142"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nomeda","family":"Girnius","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Harvard Medical School , Boston, MA 02115"},{"name":"Ludwig Center at Harvard, Harvard Medical School , Boston, MA 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman J","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-3168","authenticated-orcid":false,"given":"Yvonne J K","family":"Edwards","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond M","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-1652","authenticated-orcid":false,"given":"Roger J","family":"Davis","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-3262","authenticated-orcid":false,"given":"Michael A","family":"Brehm","sequence":"additional","affiliation":[{"name":"Program in Molecular Medicine, University of Massachusetts Medical School , Worcester, MA 01605"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"key":"2025030417560241400_r1","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/nri2115","article-title":"Life and death in peripheral T cells","volume":"7","author":"Krammer","year":"2007","journal-title":"Nat. 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