{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:46:51Z","timestamp":1789922811694,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Trafficking of dendritic cells (DCs) to lymph nodes (LNs) to present Ags is a crucial step in the pathogenesis of rheumatoid arthritis (RA). Matrix metalloproteinase-9 (MMP-9) is the key molecule for DC migration. Thus, blocking MMP-9 to inhibit DC migration may be a novel strategy to treat RA. In this study, we used anti\u2013MMP-9 Ab to treat collagen-induced arthritis (CIA) in DBA\/1J mice and demonstrated that anti\u2013MMP-9 Ab treatment significantly suppressed the development of CIA via the modulation of DC trafficking. In anti\u2013MMP-9 Ab\u2013treated CIA mice, the number of DCs in draining LNs was obviously decreased. In vitro, anti\u2013MMP-9 Ab and MMP-9 inhibitor restrained the migration of mature bone marrow\u2013derived DCs in Matrigel in response to CCR7 ligand CCL21. In addition, blocking MMP-9 decreased T and B cell numbers in LNs of CIA mice but had no direct influence on the T cell response to collagen II by CD4+ T cells purified from LNs or spleen. Besides, anti\u2013MMP-9 Ab did not impact on the expression of MHC class II, CD40, CD80, CD86, and chemokine receptors (CCR5 and CCR7) of DCs both in vivo and in vitro. Furthermore, we discovered the number of MMP-9\u2212\/\u2212 DCs trafficking from footpads to popliteal LNs was dramatically reduced as compared with wild type DCs in both MMP-9\u2212\/\u2212 mice and wild type mice. Taken together, these results indicated that DC-derived MMP-9 is the crucial factor for DC migration, and blocking MMP-9 to inhibit DC migration may constitute a novel strategy of future therapy for RA and other similar autoimmune diseases.<\/jats:p>","DOI":"10.4049\/jimmunol.1800412","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T15:25:15Z","timestamp":1541431515000},"page":"3514-3523","source":"Crossref","is-referenced-by-count":30,"title":["Blocking Matrix Metalloproteinase-9 Abrogates Collagen-Induced Arthritis via Inhibiting Dendritic Cell Migration"],"prefix":"10.1093","volume":"201","author":[{"given":"Juan","family":"He","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaochan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihu","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Han","sequence":"additional","affiliation":[{"name":"Hospital of South China Normal University , Guangzhou 510631 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University , Guangzhou 510630 ,","place":["China"]},{"name":"Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province , Guangzhou 510630 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Third Affiliated Hospital of Inner Mongolia Medical University (Inner Mongolia BaoGang Hospital) , Baotou 014010 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