{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:28:38Z","timestamp":1792553318683,"version":"4.5.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Genetic and immunological evidence clearly points to a role for T cells in the pathogenesis of rheumatoid arthritis (RA). Selective targeting of such disease-associated T cell clones might be highly effective while having few side effects. However, such selective targeting may only be feasible if the same T cell clones dominate the immune response at different sites of inflammation. We leveraged high-throughput technology to quantitatively assess whether different T cell clones dominate the inflammatory infiltrate at various sites of inflammation in this prototypic autoimmune disease. In 13 RA patients, we performed quantitative next-generation sequencing\u2013based human TCR\u03b2 repertoire analysis in simultaneously obtained samples from inflamed synovial tissue (ST) from distinct locations within one joint, from multiple joints, and from synovial fluid (SF) and peripheral blood (PB). Identical TCR\u03b2 clones dominate inflammatory responses in ST samples taken from different locations within a single joint and when sampled in different joints. Although overall ST\u2013SF overlap was comparable to higher ST\u2013ST values, the overlap in dominant TCR\u03b2 clones in ST\u2013SF comparisons was much lower than ST\u2013ST and comparable to the low ST\u2013PB overlap. In individual RA patients, a limited number of TCR\u03b2 clones dominate the immune response in the inflamed ST regardless of the location within a joint and which joint undergoes biopsy; in contrast, there is limited overlap of ST with SF or PB TCR repertoires. This limited breadth of the T cell response in ST of the individual RA patient indicates that development of immunotherapies that selectively modulate dominant T cell responses might be feasible.<\/jats:p>","DOI":"10.4049\/jimmunol.1800421","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T15:35:21Z","timestamp":1528731321000},"page":"417-422","source":"Crossref","is-referenced-by-count":48,"title":["In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones"],"prefix":"10.1093","volume":"201","author":[{"given":"Anne","family":"Musters","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L","family":"Klarenbeek","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]},{"name":"Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieke E","family":"Doorenspleet","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]},{"name":"Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3476-993X","authenticated-orcid":false,"given":"Giulia","family":"Balzaretti","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]},{"name":"Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E E","family":"Esveldt","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]},{"name":"Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-8127","authenticated-orcid":false,"given":"Barbera D C","family":"van Schaik","sequence":"additional","affiliation":[{"name":"Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Jongejan","sequence":"additional","affiliation":[{"name":"Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander W","family":"Tas","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Rheumatology, Amsterdam Rheumatology and Immunology Center, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]},{"name":"Laboratory of Experimental Immunology, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1025-7232","authenticated-orcid":false,"given":"Antoine H C","family":"van Kampen","sequence":"additional","affiliation":[{"name":"Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam , 1105 AZ Amsterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3912-5428","authenticated-orcid":false,"given":"Frank","family":"Baas","sequence":"additional","affiliation":[{"name":"Laboratory for Genome Analysis, 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