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There are currently no efficient therapeutic methods or effective prophylactics. In this study, we isolated the mAb A6-1 from an EV-D68\u2013infected rhesus macaque (Macaca mulatta) and found that the Ab provided effective protection in EV-D68 intranasally infected suckling mice. We observed that A6-1 bound to the DE loop of EV-D68 VP1 and interfered with the interaction between the EV-D68 virus and \u03b12,6-linked sialic acids of the host cell. The production of A6-1 and its Ab properties present a bridging study for EV-D68 vaccine design and provide a tool for analyzing the process by which Abs can inhibit EV-D68 infection.<\/jats:p>","DOI":"10.4049\/jimmunol.1800655","type":"journal-article","created":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T15:18:56Z","timestamp":1538579936000},"page":"2557-2569","source":"Crossref","is-referenced-by-count":22,"title":["A Novel Neutralizing Antibody Specific to the DE Loop of VP1 Can Inhibit EV-D68 Infection in Mice"],"prefix":"10.1093","volume":"201","author":[{"given":"Huiwen","family":"Zheng","sequence":"first","affiliation":[{"name":"Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College , Kunming 650118","place":["China"]},{"name":"Key Laboratory of Systemic Innovative Research on Virus Vaccine, Chinese Academy of Medical Sciences , Kunming 650118 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