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We identified a role for BMP signaling in regulating macrophage responses to Candida albicans infection during wound repair in a murine model. In this study, the RNA binding protein, AU-rich element\u2013binding factor 1, was posttranslationally destabilized to bring about ubiquitin ligase, NEDD4-directed activation of BMP signaling. Concomitantly, PI3K\/PKC\u03b4 mobilized the rapid phosphorylation of BMP-responsive Smad1\/5\/8. Activated BMP pathway orchestrated the elevated recruitment of EZH2 at promoters of genes assisting timely wound closure. In vivo, the repressive H3K27 trimethylation was observed to persist, accompanied by a robust upregulation of BMP pathway upon infection with C. albicans, culminating in delayed wound healing. Altogether, we uncovered the signaling networks coordinated by fungal colonies that are now increasingly associated with the infected wound microbiome, resulting in altered wound fate.<\/jats:p>","DOI":"10.4049\/jimmunol.1800688","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T16:25:13Z","timestamp":1542212713000},"page":"3617-3629","source":"Crossref","is-referenced-by-count":6,"title":["Deregulated AUF1 Assists BMP-EZH2\u2013Mediated Delayed Wound Healing during <i>Candida albicans<\/i> Infection"],"prefix":"10.1093","volume":"201","author":[{"given":"Kasturi","family":"Mahadik","sequence":"first","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science , Bangalore, Karnataka 560012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preeti","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science , Bangalore, Karnataka 560012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science , Bangalore, Karnataka 560012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-0928","authenticated-orcid":false,"given":"Riyaz Ahmad","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science , Bangalore, Karnataka 560012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kithiganahalli Narayanaswamy","family":"Balaji","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Cell Biology, Indian Institute of Science , Bangalore, Karnataka 560012 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,12,15]]},"reference":[{"key":"2025030417580015000_r1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.chom.2017.11.009","article-title":"Leukotriene B4-mediated neutrophil recruitment causes pulmonary capillaritis during lethal fungal sepsis","volume":"23","author":"Lee","year":"2018","journal-title":"Cell Host Microbe"},{"key":"2025030417580015000_r2","doi-asserted-by":"crossref","first-page":"40","DOI":"10.12968\/jowc.2011.20.1.40","article-title":"Survey of fungi and yeast in polymicrobial infections in chronic wounds","volume":"20","author":"Dowd","year":"2011","journal-title":"J. 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