{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:46:23Z","timestamp":1761597983547,"version":"3.38.0"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>HSV type 1 (HSV-1)\u2013specific CD8+ T cells protect from herpes infection and disease. However, the nature of protective CD8+ T cells in HSV-1 seropositive healthy asymptomatic (ASYMP) individuals (with no history of clinical herpes disease) remains to be determined. In this study, we compared the phenotype and function of HSV-specific CD8+ T cells from HLA-A*02:01\u2013positive ASYMP and symptomatic (SYMP) individuals (with a documented history of numerous episodes of recurrent ocular herpetic disease). We report that although SYMP and ASYMP individuals have similar frequencies of HSV-specific CD8+ T cells, the \u201cnaturally\u201d protected ASYMP individuals have a significantly higher proportion of multifunctional HSV-specific effector memory CD8+ T cells (CD73+CD45RAhighCCR7lowCD8+ effector memory RA (TEMRA) and CD73+CD45RAlowCCR7lowCD8+ effector memory (TEM) as compared with SYMP individuals. Similar to humans, HSV-1\u2013infected ASYMP B6 mice had frequent multifunctional HSV-specific CD73+CD8+ T cells in the cornea, as compared with SYMP mice. Moreover, in contrast to wild type B6, CD73\u2212\/\u2212 deficient mice infected ocularly with HSV-1 developed more recurrent corneal herpetic infection and disease. This was associated with less functional CD8+ T cells in the cornea and trigeminal ganglia, the sites of acute and latent infection. The phenotypic and functional characteristics of HSV-specific circulating and in situ CD73+CD8+ T cells, demonstrated in both ASYMP humans and mice, suggest a positive role for effector memory CD8+ T cells expressing the CD73 costimulatory molecule in the protection against ocular herpes infection and disease. These findings are important for the development of safe and effective T cell\u2013based herpes immunotherapy.<\/jats:p>","DOI":"10.4049\/jimmunol.1800725","type":"journal-article","created":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T15:45:25Z","timestamp":1536594325000},"page":"2315-2330","source":"Crossref","is-referenced-by-count":11,"title":["Phenotypic and Functional Signatures of Herpes Simplex Virus\u2013Specific Effector Memory CD73+CD45RAhighCCR7lowCD8+ TEMRA and CD73+CD45RAlowCCR7lowCD8+ TEM Cells Are Associated with Asymptomatic Ocular Herpes"],"prefix":"10.1093","volume":"201","author":[{"given":"Ruchi","family":"Srivastava","sequence":"first","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine, CA 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Gr\u00e9goire","family":"Coulon","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine, CA 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-7371","authenticated-orcid":false,"given":"Soumyabrata","family":"Roy","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine, CA 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sravya","family":"Chilukuri","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine, CA 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-0771","authenticated-orcid":false,"given":"Sumit","family":"Garg","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine, CA 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lbachir","family":"BenMohamed","sequence":"additional","affiliation":[{"name":"Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine , Irvine, CA 92697"},{"name":"Department of Molecular Biology and Biochemistry, University of California Irvine, School of Medicine , Irvine, CA 92697"},{"name":"Institute for Immunology, University of California Irvine, School of Medicine , Irvine, CA 92697"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"2025030417573570200_r1","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.4049\/jimmunol.1301415","article-title":"Asymptomatic HLA-A*02:01-restricted epitopes from herpes simplex virus glycoprotein B preferentially recall polyfunctional CD8+ T cells from seropositive asymptomatic individuals and protect HLA transgenic mice against ocular herpes","volume":"191","author":"Dervillez","year":"2013","journal-title":"J. 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