{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:46:27Z","timestamp":1741153587245,"version":"3.38.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An unbalance between Abs that recognize an autoantigen (idiotypes; IDs) and Igs that bind such Abs (anti-IDs) is considered a functional event in autoimmune disorders. We investigated the presence of an ID\/anti-ID network in celiac disease (CD), a condition in which antitissue transglutaminase 2 (TG2) Abs are suspected to contribute to CD pathogenesis. To characterize the ID side, we reproduced by in vitro yeast display the intestine-resident Abs from CD and control patients. These TG2-specific IDs were used to identify potential anti-IDs in the serum. We observed elevated titers of anti-IDs in asymptomatic patients with predisposition to CD and demonstrated that anti-ID depletion from the serum restores a detectable humoral response against TG2. Our study provides an alternative approach to quantify CD-related autoantibodies in cases that would be defined \u201cnegative serology\u201d with current diagnostic applications. Therefore, we suggest that developments of this technology could be designed for perspective routine tests.<\/jats:p>","DOI":"10.4049\/jimmunol.1800819","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T22:35:13Z","timestamp":1547246113000},"page":"1079-1087","source":"Crossref","is-referenced-by-count":4,"title":["A Functional Idiotype\/Anti-Idiotype Network Is Active in Genetically Gluten-Intolerant Individuals Negative for Both Celiac Disease\u2013Related Intestinal Damage and Serum Autoantibodies"],"prefix":"10.1093","volume":"202","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2515-8229","authenticated-orcid":false,"given":"Sara","family":"Quaglia","sequence":"first","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricerca e Cura a Carattere Scientifico Burlo Garofolo , Trieste 34137 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fortunato","family":"Ferrara","sequence":"additional","affiliation":[{"name":"Specifica Inc. , Santa Fe, NM 87505"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4013-1630","authenticated-orcid":false,"given":"Luigina","family":"De Leo","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricerca e Cura a Carattere Scientifico Burlo Garofolo , Trieste 34137 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9748-902X","authenticated-orcid":false,"given":"Fabiana","family":"Ziberna","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricerca e Cura a Carattere Scientifico Burlo Garofolo , Trieste 34137 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9454-381X","authenticated-orcid":false,"given":"Serena","family":"Vatta","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricerca e Cura a Carattere Scientifico Burlo Garofolo , Trieste 34137 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8214-0776","authenticated-orcid":false,"given":"Serena","family":"Marchi\u00f2","sequence":"additional","affiliation":[{"name":"Candiolo Cancer Institute-Fondazione del Piemonte per l\u2019Oncologia, Istituto di Ricerca e Cura a Carattere Scientifico , Candiolo, Turin 10060 ,","place":["Italy"]},{"name":"Department of Oncology, University of Turin School of Medicine , Candiolo, Turin 10060 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-242X","authenticated-orcid":false,"given":"Daniele","family":"Sblattero","sequence":"additional","affiliation":[{"name":"University of Trieste, Department of Life Science , Trieste 34128 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Ventura","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricerca e Cura a Carattere Scientifico Burlo Garofolo , Trieste 34137 ,","place":["Italy"]},{"name":"University of Trieste, Department of Life Science , Trieste 34128 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarcisio","family":"Not","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health, Istituto di Ricerca e Cura a Carattere Scientifico Burlo Garofolo , Trieste 34137 ,","place":["Italy"]},{"name":"University of Trieste, Department of Life Science , Trieste 34128 ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"2025030417560519700_r1","first-page":"373","article-title":"Towards a network theory of the immune system","volume":"125C","author":"Jerne","year":"1974","journal-title":"Ann. 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