{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:48:02Z","timestamp":1790365682570,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Killer-cell Ig-like receptor (KIR) genes are inherited as haplotypes. They are expressed by NK cells and linked to outcomes of infectious diseases and pregnancy in humans. Understanding how genotype relates to phenotype is difficult because of the extensive diversity of the KIR family. Indeed, high-resolution KIR genotyping and phenotyping in single NK cells in the context of disease association is lacking. In this article, we describe a new method to separate NK cells expressing allotypes of the KIR2DL1 gene carried by the KIR A haplotype (KIR2DL1A) from those expressing KIR2DL1 alleles carried by the KIR B haplotype (KIR2DL1B). We find that in KIR AB heterozygous individuals, different KIR2DL1 allotypes can be detected in both peripheral blood and uterine NK cells. Using this new method, we demonstrate that both blood and uterine NK cells codominantly express KIR2DL1A and KIR2DL1B allotypes but with a predominance of KIR2DL1A variants, which associate with enhanced NK cell function. In a case-control study of pre-eclampsia, we show that KIR2DL1A, not KIR2DL1B, associates with increased disease risk. This method will facilitate our understanding of how individual KIR2DL1 allelic variants affect NK cell function and contribute to disease risk.<\/jats:p>","DOI":"10.4049\/jimmunol.1800860","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T11:04:31Z","timestamp":1537787071000},"page":"2593-2601","source":"Crossref","is-referenced-by-count":36,"title":["High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia"],"prefix":"10.1093","volume":"201","author":[{"given":"Ois\u00edn","family":"Huhn","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, National Institute for Health Research Cambridge Biomedical Research Centre , Cambridge CB2 0SW ,","place":["United Kingdom"]},{"name":"Centre for Trophoblast Research, University of Cambridge , Cambridge CB2 3EG ,","place":["United Kingdom"]},{"name":"MedImmune Ltd. , Granta Park, Cambridge CB21 6GH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-7808","authenticated-orcid":false,"given":"Olympe","family":"Chazara","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research, University of Cambridge , Cambridge CB2 3EG ,","place":["United Kingdom"]},{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-1331","authenticated-orcid":false,"given":"Martin A","family":"Ivarsson","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research, University of Cambridge , Cambridge CB2 3EG ,","place":["United Kingdom"]},{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United Kingdom"]},{"name":"Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital , Stockholm ,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Reti\u00e8re","sequence":"additional","affiliation":[{"name":"Etablissement Fran\u00e7ais du Sang, Universit\u00e9 de Nantes , 44011 Nantes ,","place":["France"]},{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Nantes Angers, INSERM , CNRS, Universit\u00e9 de Nantes, 44007 Nantes ,","place":["France"]},{"name":"Centre de Recherche en Canc\u00e9rologie et Immunologie Nantes Angers, INSERM U1232 , CNRS, Universit\u00e9 d'Angers, 49035 Angers ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-2308","authenticated-orcid":false,"given":"Timothy C","family":"Venkatesan","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United 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,","place":["United Kingdom"]},{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6003-8559","authenticated-orcid":false,"given":"James A","family":"Traherne","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0150-5698","authenticated-orcid":false,"given":"John","family":"Trowsdale","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research, University of Cambridge , Cambridge CB2 3EG ,","place":["United Kingdom"]},{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United 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94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hormas","family":"Ghadially","sequence":"additional","affiliation":[{"name":"MedImmune Ltd. , Granta Park, Cambridge CB21 6GH ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-9073","authenticated-orcid":false,"given":"Ashley","family":"Moffett","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research, University of Cambridge , Cambridge CB2 3EG ,","place":["United Kingdom"]},{"name":"Department of Pathology, University of Cambridge , Cambridge CB2 1QP ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-7748","authenticated-orcid":false,"given":"Andrew M","family":"Sharkey","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research, University of Cambridge , Cambridge CB2 3EG ,","place":["United 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