{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T06:12:36Z","timestamp":1792390356813,"version":"4.4.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Immune senescence is a significant contributor to health problems in the developed world and may be accelerated by chronic viral infections. To date, there have been few studies of immune function in healthy older people in sub-Saharan Africa. We assessed T cell and B cell phenotypes and immune responses to CMV, EBV, and influenza virus in Malawians aged 20\u201369 y. Notably, the proportion of naive (CCR7+CD45RA+) CD4 and CD8 T cells was only 14% of the lymphoid repertoire even in donors aged under 30 y but did not decrease further with age. A small increase in the late differentiated (CD27\u2212CD28\u2212) CD8 T cell subpopulation was observed in older donors but the CD4\/CD8 T cell ratio remained stable in all age groups. Interestingly, the regulatory (CD25hiFOXP3hi) T cell subpopulation was small in all age groups, and we observed no age-associated accumulation of cells expressing the senescence- and exhaustion-associated markers CD57 and PD-1. We assessed functional T cell responses to mitogenic and viral antigenic stimulation by the expression of CD154, IFN-\u03b3, TNF-\u03b1, IL-2, and IL-17 and proliferation. All responses were robust across the life course, although we observed an age-associated shift from IFN-\u03b3 to TNF-\u03b1 in the response to EBV. In summary, we found the naive T cell subpopulation of young adult Malawians was smaller than in their contemporaries in high-income settings but remains stable thereafter and that lymphocyte function is retained across the life course. These observations indicate that studies of the genetic and environmental factors influencing immune function in different environments may provide insights into minimizing immune ageing.<\/jats:p>","DOI":"10.4049\/jimmunol.1800866","type":"journal-article","created":{"date-parts":[[2019,7,29]],"date-time":"2019-07-29T15:15:11Z","timestamp":1564413311000},"page":"1160-1171","source":"Crossref","is-referenced-by-count":4,"title":["Early T Cell Differentiation with Well-Maintained Function across the Adult Life Course in Sub-Saharan Africa"],"prefix":"10.1093","volume":"203","author":[{"given":"David J C","family":"Miles","sequence":"first","affiliation":[{"name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme , Chichiri, Blantyre 3 ,","place":["Malawi"]},{"name":"Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Birmingham Health Partners, University of Birmingham , Edgbaston, B15 2TT Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Shumba","sequence":"additional","affiliation":[{"name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme , Chichiri, Blantyre 3 ,","place":["Malawi"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Pachnio","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Birmingham Health Partners, University of Birmingham , Edgbaston, B15 2TT Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4230-3099","authenticated-orcid":false,"given":"Jusnara","family":"Begum","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Birmingham Health Partners, University of Birmingham , Edgbaston, B15 2TT Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth L","family":"Corbett","sequence":"additional","affiliation":[{"name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme , Chichiri, Blantyre 3 ,","place":["Malawi"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-449X","authenticated-orcid":false,"given":"Robert S","family":"Heyderman","sequence":"additional","affiliation":[{"name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme , Chichiri, Blantyre 3 ,","place":["Malawi"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6895-1967","authenticated-orcid":false,"given":"Paul","family":"Moss","sequence":"additional","affiliation":[{"name":"Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, Birmingham Health Partners, University of Birmingham , Edgbaston, B15 2TT Birmingham ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,1]]},"reference":[{"key":"2025030417541417300_r1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.humimm.2006.10.019","article-title":"Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly","volume":"68","author":"Weinberger","year":"2007","journal-title":"Hum. 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