{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:31:37Z","timestamp":1777516297900,"version":"3.51.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Yersinia enterocolitica causes a severe enteric infection in infants and young children. There is no vaccine approved for use in humans. We investigated the immunogenicity and protective capacity of Yersinia YopB, a conserved type III secretion system protein, alone or combined with LcrV in adult mice immunized intranasally. YopB or LcrV (5 \u03bcg) administered with the Escherichia coli double mutant heat-labile toxin (dmLT) adjuvant afforded modest (10\u201330%) protection against lethal Y. enterocolitica oral infection. The combination of YopB and LcrV (5 \u03bcg each) dramatically improved vaccine efficacy (70\u201380%). Additionally, it afforded complete protection against Y. pestis pulmonary infection. Immunization with YopB\/LcrV+dmLT resulted in Ag-specific serum IgG, systemic and mucosal Ab-secreting cells, as well as IFN-\u03b3, TNF-\u03b1, IL-2, IL-6, IL-17A, and KC production by spleen cells. Serum Abs elicited by YopB\/LcrV+dmLT had enhanced bactericidal and opsonophagocytic killing activity. After Y. enterocolitica challenge, YopB\/LcrV+dmLT\u2013vaccinated mice exhibited intact intestinal tissue, active germinal centers in mesenteric lymph nodes, IgG+ and IgA+ plasmablasts in the lamina propria, and Abs in intestinal fluid. On the contrary, complete tissue destruction and abscesses were seen in placebo recipients that succumbed to infection. Mice immunized as infants with YopB+dmLT or LcrV+dmLT achieved 60% protection against lethal Y. enterocolitica infection, and vaccine efficacy increased to 90\u2013100% when they received YopB\/LcrV+dmLT. YopB+dmLT also afforded substantial (60%) protection when administered intradermally to infant mice. YopB\/LcrV+dmLT is a promising subunit vaccine candidate with the potential to elicit broad protection against Yersinia spp.<\/jats:p>","DOI":"10.4049\/jimmunol.1800985","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T20:21:28Z","timestamp":1550694088000},"page":"2005-2016","source":"Crossref","is-referenced-by-count":8,"title":["A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity against <i>Yersinia<\/i> Infection in Adult and Infant Mice"],"prefix":"10.1093","volume":"202","author":[{"given":"Shannon J","family":"Heine","sequence":"first","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Department of Pediatrics, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-774X","authenticated-orcid":false,"given":"Olga L","family":"Franco-Mahecha","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Department of Pediatrics, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khandra T","family":"Sears","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthia B","family":"Drachenberg","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten L","family":"van Roosmalen","sequence":"additional","affiliation":[{"name":"Mucosis BV , Groningen 9713 GX ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kees","family":"Leenhouts","sequence":"additional","affiliation":[{"name":"Mucosis BV , Groningen 9713 GX ,","place":["the Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy L","family":"Picking","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, University of Kansas , Lawrence, KS 66047"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0894-4009","authenticated-orcid":false,"given":"Marcela F","family":"Pasetti","sequence":"additional","affiliation":[{"name":"Center for Vaccine Development and Global Health, University of Maryland School of Medicine , Baltimore, MD 21201"},{"name":"Department of Pediatrics, University of Maryland School of Medicine , Baltimore, MD 21201"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,4,1]]},"reference":[{"key":"2025030417561352900_r1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1286-4579(99)80028-8","article-title":"Yersinia enterocolitica: overview and epidemiologic correlates","volume":"1","author":"Bottone","year":"1999","journal-title":"Microbes Infect."},{"key":"2025030417561352900_r2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1521-6942(02)00104-3","article-title":"Arthritis associated with enteric infection","volume":"17","author":"Hill Gaston","year":"2003","journal-title":"Best Pract. 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